PCT、CRP、IL-6及肺功能指标与儿童喘息性肺炎严重程度的关系

Relationship among PCT,CRP,IL-6,Lung Function Index and Severity of Asthmatic Pneumonia in Children

目的:探讨降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)及肺功能指标与儿童喘息性肺炎严重程度的关系。方法:选取2021年10月—2022年10月福建医科大学附属闽东医院收治的126例喘息性肺炎患儿为研究对象。收集所有患儿的临床资料,根据病情的严重程度将所有患儿分为轻中度组和重度组。分析分组情况,并比较两组临床资料,分析肺功能指标及PCT、CRP、IL-6与儿童喘息性肺炎严重程度的相关性。结果:126例喘息性肺炎患儿中轻中度患儿87例,重度患儿39例。轻中度组CRP、IL-6、PCT水平均低于重度组患儿,第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、FEV_(1)占预计值的百分比(FEV_(1)%pred)、FEV_(1)占FVC的比值(forced expiratory volume in one second/forced vital capacity,FEV_(1)/FVC%)、呼气峰流速(peak expiratory flow,PEF)均高于重度组,差异有统计学意义(P<0.05)。儿童喘息性肺炎严重程度与PCT、CRP、IL-6水平均呈正相关,与FEV_(1)、FVC、FEV_(1)pred%、FEV_(1)/FVC%、PEF均呈负相关(P<0.05)。结论:PCT、CRP、IL-6及肺功能指标与儿童喘息性肺炎病情严重程度密切相关,对临床诊疗有着较强的指导意义。

Objective:To explore the relationship among procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6),lung function index and severity of asthmatic pneumonia in children.Method:A total of 126 children with asthmatic pneumonia admitted to Mindong Hospital Affiliated to Fujian Medical University from October 2021 to October 2022 were selected as the study objects.The clinical data of all the children were collected and divided into mild to moderate group and severe group according to the severity of the disease.The group condition was analyzed,and the clinical data of the two groups were compared,the correlation among lung function indexes,PCT,CRP,IL-6 and the severity of asthmatic pneumonia in children was analyzed.Result:Among 126 children with asthmatic pneumonia,87 cases were mild to moderate,and 39 cases were severe.The levels of CRP,IL-6 and PCT in mild to moderate group were lower than those in severe group,and forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),percentage of FEV_(1) to predicted value(FEV_(1)%pred),ratio of FEV_(1) to FVC(forced expiratory volume in one second/forced vital capacity,FEV_(1)/FVC%)and peak expiratory flow(PEF)were higher than those in the severe group,the differences were statistically significant(P<0.05).The severity of asthmatic pneumonia in children was positively correlated with the levels of PCT,CRP and IL-6,and negatively correlated with the levels of FEV_(1),FVC,FEV_(1)pred%,FEV_(1)/FVC%and PEF(P<0.05).Conclusion:PCT,CRP,IL-6 and lung function indexes are closely related to the severity of disease in children with asthmatic pneumonia,which has a strong guiding significance for clinical diagnosis and treatment.