新生化颗粒治疗对药物流产患者阴道血流及宫内残留物情况的影响

Effect of Xinshenghua granule on vaginal bloodflow and intrauterine residue in patients with drug abortion

目的探讨新生化颗粒治疗对药物流产患者阴道血流及宫内残留物情况的影响。方法选取70例药物流产患者,采用随机数字表法分为试验组与对照组,每组35例。对照组予以缩宫素治疗,试验组在对照组基础上加用新生化颗粒治疗。比较两组患者的阴道血流及宫内残留物情况。结果试验组患者的阴道出血量显著少于对照组,阴道出血时间、宫内残留物排出时间及月经恢复时间均显著短于对照组(P<0.05)。治疗前,两组子宫体积、子宫内膜厚度比较,差异无统计学意义(P>0.05);试验组患者治疗后的子宫体积、子宫内膜厚度均显著小于对照组(P<0.05)。治疗前,两组血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05);试验组患者治疗后的血清IL-6、TNF-α及hs-CRP水平均显著低于对照组(P<0.05)。结论新生化颗粒治疗可有效缓解药物流产患者机体微炎症状态,促进宫内残留物快速排出,控制子宫体积及内膜厚度,促进月经周期规律恢复,有利于子宫复旧。

Objective To explore the effect of Xinshenghua granule on vaginal bloodflow and intrauterine residue in patients with drug abortion.Methods 70 patients with drug abortion were selected and divided into experimental group and control group by random number table method,with 35 cases in each group.The control group was treated with oxytocin,and the experimental group was treated with Xinshenghua granule.The vaginal blood flow and intrauterine residue were compared between the two groups.Results The amount of vaginal bleeding in experimental group was significantly less than that in control group,and the time of vaginal bleeding,intrauterine residue discharge and menstrual recovery time were significantly shorter than that in control group(P<0.05).Before treatment,there were no significant differences in uterine volume and endometrial thickness between the two groups(P>0.05).The uterine volume and endometrial thickness of experimental group were significantly lower than those of control group after treatment(P<0.05).Before treatment,there were no significant differences in serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)between 2 groups(P>0.05).The serum levels of IL-6,TNF-αand hs-CRP in experimental group were significantly lower than those in control group after treatment(P<0.05).Conclusion Xinshenghua granule can effectively relieve the micro-inflammatory state of the body of the patients with medical abortion,promote the rapid discharge of intrauterine residues,control the volume and thickness of the uterus,promote the regular recovery of menstrual cycle,and is conducive to uterine involution.