Cronkhite-Canada综合征:临床特征和治疗

Cronkhite-Canada syndrome:from clinical features to treatment

Cronkhite-Canada综合征(CCS)是一种罕见的病因不明的获得性息肉病。目前全球已有超过500例的报道。CCS的典型表现是胃肠道症状(如腹泻)和皮肤改变(如脱发、色素沉着和指甲萎缩)。内镜特征包括分布于除食管外整个胃肠道的弥漫性息肉,这些息肉的病理类型主要包括炎性、增生性、错构性及腺瘤性息肉。CCS可并发许多疾病,而且有一定的恶性倾向,病死率较高。目前CCS尚无统一的标准治疗方案。本文对目前所有报道的CCS病例进行综述,旨在提高对该病的认识。

Cronkhite-Canada syndrome(CCS)is a rare acquired polyposis with unknown etiology.To date,>500 cases have been reported worldwide.CCS is typically characterized by gastrointestinal symptoms,such as diarrhea and skin changes(e.g.alopecia,pigmentation,and nail atrophy).Endoscopic features include diffuse polyps throughout the entire gastrointestinal tract,except for the esophagus.Pathological types of polyps in CCS mainly include inflammatory,hyperplastic,hamartomatous,and adenomatous polyps.CCS can be complicated by many diseases and has a canceration tendency with a high mortality rate.Moreover,there is no uniform standard treatment for CCS.A review of the reported cases of CCS is presented herein,with the goal of improving our understanding of this disease.