摘要
Accumulation of impaired mitochondria and energy metabolism disorders are non-negligible features of both aging and age-related neurodegeneration,including Alzheimer’s disease(AD).A growing number of studies suggest that mitophagy disorders play an important role in AD occurrence and development.The interaction between mitophagy deficits and Aβor Tau pathology may form a vicious cycle and cause neuronal damage and death.Elucidating the molecular mechanism of mitophagy and its role in AD may provide insights into the etiology and mechanisms of AD.Defective mitophagy is a potential target for AD prevention and treatment.
基金
grants from National Natural Science Foundation of China(31929002,92049107 and 81801077)
Innovative Research Groups of the National Natural Science Foundation of China(81721005)
Youth Program of Wuhan Municipal Health Commission Foundation(WX18Q41)
Technology and Innovation Commission of Shenzhen Municipality(JCYJ20210324141405014)
Guangdong Basic and Applied Basic Research Foundation(2020B1515120017)and the Academic Frontier Youth Team Project to Xiaochuan Wang from Huazhong University of Science and Technology.
