柚皮素治疗骨质疏松的作用机制研究

Research progress in the mechanism of naringenin in the treatment of osteoporosis

骨质疏松是一种以骨质量减少、骨显微结构发生退化、骨脆性增加为特征的全身性机体骨代谢性疾病。随着老龄化社会的到来,骨质疏松的发病率在逐年上升。柚皮素是一种天然存在的二氢黄酮类化合物,该文基于国内外最新的研究,分析并讨论了柚皮素通过调控CD4+T细胞、模拟雌激素作用以及抑制P38信号通路和促进SDF-1/CXCR4信号通路来治疗骨质疏松的作用机制,以证实其抑制破骨和促进成骨的作用。以期为柚皮素安全、有效、合理地开发利用提供理论依据,为骨质疏松的预防及治疗探索一种新的解决思路。

Osteoporosis is a systemic bone metabolic disease characterized by the decrease of bone quality,the degeneration of bone microstructure,and the increase of bone fragility.With the advent of the aging society,the incidence of osteoporosis is increasing year by year.Naringenin is a natural exist dihydroflavonoid.Based on the latest national and international research,this article analyzes and discusses the mechanism of naringenin in the treatment of osteoporosis by regulating CD4+T cells,mimicking the effect of estrogen,inhibiting P38 signaling pathway,and promoting SDF-1/CXCR4 signaling pathway to confirm its effect on inhibiting osteoclast and promoting osteogenesis.It is expected to provide a theoretical basis for the safe,effective,and reasonable development and utilization of naringenin,and to explore a new solution for the prevention and treatment of osteoporosis.