猪流行性腹泻病毒与宿主细胞互作研究进展

Research Progress on Interactions of Porcine Epidemic Diarrhea Virus with Host Cells

猪流行性腹泻病毒(PEDV)是导致仔猪腹泻最常见的病原之一。猪流行性腹泻(PED)自1971年被发现后,至今仍对全球养猪业造成巨大威胁,给我国养猪业造成了严重的经济损失。为成功建立感染并能够在宿主体内进行高效复制和扩散,PEDV需要与宿主细胞进行紧密的互作。因此,了解PEDV与宿主细胞的相互作用是阐明病毒致病机制的基础和疫病防控的前提。本文从四个方面对PEDV与宿主细胞互作的研究进展进行了综述,包括PEDV与细胞受体和内体系统的互作、PEDV与宿主细胞基因转录和蛋白合成系统的互作、PEDV与宿主细胞内质网应激系统及细胞凋亡系统的互作,以及PEDV与宿主细胞天然免疫系统的互作。

Porcine epidemic diarrhea virus(PEDV)is one of the most common pathogens causing diarrheal diseases in piglets.Porcine epidemic diarrhea was discovered in 1971 and still poses a huge threat to the pig industry on the world.In order to successfully establish infection and efficiently replicate in the hosts,PEDV needs to interact closely with host cells.Therefore,understanding the interactions between the pathogen PEDV and the host cells is the basis for investigating the pathogenic mechanism and prerequisite for disease prevention and control.This review summarized the research progress on the interactions between PEDV and host cells from the following four aspects:interaction between PEDV and cellular receptors and endosome system,interaction between PEDV and host cell gene transcription and protein synthesis system,interaction of PEDV with endoplasmic reticulum stress system and apoptosis system of host cells,and interaction between PEDV and host cellular innate immune system.