摘要
This review aimed to assess the occurrence of false-positive serological reaction between dengue and coronavirus disease 2019(COVID-19)and its implications for diagnosis.Evidence syntheses were conducted by systematically reviewing available literature using multiple databases,including Web of Science,PubMed,Google Scholar and medRxiv.Among a total of 16 presented cases from clinical settings,cross-reaction to COVID-19 serological tests was observed in two(12.5%)dengue-positive patients,while 14 patients(87.5%)confirmed positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)showed a cross-reaction with dengue serological tests,leading to misdiagnosis and mismanagement by attending clinicians.Of 1789 SARS-CoV-2-positive sera,cross-reaction to dengue serological tests was observed in 180 sera(10%),which is higher than the cross-reaction observed for SARS-CoV-2 in archived pre-COVID-19 sera positive for a dengue infection(75 of 811,9.2%,P=0.674).Clinicians in tropical regions are therefore advised to interpret serological tests with caution and use a more pragmatic approach to triage these infections.
