门头沟地区急性脑梗死患者相关危险因素及临床干预治疗后指标变化分析

Analysis of risk factors related to acute cerebral infarction in Mentougou area and changes in indicators after clinical intervention and treatment

目的探究本地区急性脑梗死相关危险因素及干预治疗后指标变化情况。方法本研究以2020年12月至2021年12月于本医院门诊就诊及住院的急性脑梗死患者为观察组,同期就诊的排除脑梗死的健康人群为对照组,收集人口学信息、血脂、血糖(Glu)及同型半胱氨酸(Hcy)等检验指标进行比较,以探究急性脑梗死相关危险因素并比较脑梗死组经治疗后这些相关危险因素的变化。结果共纳入260例受试者,脑梗死组年龄、性别(男性)、高血压、糖尿病,吸烟、饮酒、同型半胱氨酸(HCY)、血糖(Glu)、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(LDL-c/HDL-c)值、非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇(non-HDL-c/HDL-c)值、载脂蛋白B/载脂蛋白AI(ApoB/ApoAI)值高于对照组(P<0.05),差异具有统计学意义;高密度脂蛋白胆固醇(HDL-C)、ApoAI低于对照组(P<0.05),差异有统计学意义。急性脑梗死患者,经干预治疗后检测ApoAI高于治疗前,non-HDL-c/HDL-c值、ApoB/ApoAI值、HCY低于治疗前(P<0.05),差异具有统计学意义。结论脑梗死患者non-HDL-c/HDL-c值、ApoAI、ApoB/ApoAI值等指标仍需积极干预,本研究经治疗后效果显著。

Objective To evaluate the difference of biochemical indicators of blood lipid in the acute cerebral infarction group and the analysis of intervention treatment results.Methods This study was conducted between December 2020 and December 2021 to investigate the risk factors associated with acute cerebral infarction.The observation group consisted of patients who received treatment for acute cerebral infarction during this period,while the control group comprised healthy population excluding cerebral infarction who received concurrent medical treatment at the same hospital within the same timeframe.General clinical data,blood lipid levels,blood glucose levels(Glu),and homocysteine(HCY)levels were collected and compared between the two groups to identify potential risk factors for acute cerebral infarction.Additionally,changes in these risk factors after treatment were compared within the cerebral infarction group.Results A total of 260 subjects were included in this study.Demographic characteristics such as age,male gender,hypertension,and diabetes mellitus were significantly higher in the cerebral infarction group compared to the control group(P<0.05).Additionally,risk factors including smoking,alcohol consumption,homocysteine(Hcy),blood glucose levels(Glu),low-density lipoprotein/high-density lipoprotein cholesterol(LDL-c/HDL-c),and non-HDL-c/HDL-c were significantly higher in the cerebral infarction group than in the control group(P<0.05).Furthermore,levels of high-density lipoprotein(HDL-C)and apolipoprotein A1(ApoAI)were significantly lower in the cerebral infarction group compared to the control group(P<0.05).In patients with acute cerebral infarction,interventions led to significant improvements in ApoAI levels,which increased after intervention relative to pre-intervention levels.Conversely,levels of non-HDL-c/HDL-c values,ApoB/ApoAI values,and Hcy were significantly lower after intervention than before intervention(P<0.05).These findings suggest that interventions can lead to improved lipid and homocysteine profiles in patients with acute cerebral infarction.Conclusion The study found significant differences in non-HDL-c/HDL-c values,ApoAI levels,and ApoB/ApoAI values between patients with cerebral infarction and controls.These differences were further improved by intervention treatment.These findings suggest that targeted interventions aimed at improving lipid and homocysteine profiles could potentially reduce the incidence of acute cerebral infarction.