不同临床病理特征乳腺癌患者CK5/6、EGFR、AR、Ki67表达情况及临床指导意义

Expressions of CK5/6,EGFR,AR and Ki67 in breast cancer patients with different clinicopathological features and their clinical significance

目的探讨不同临床病理特征乳腺癌患者细胞角蛋白5/6(CK5/6)、表皮生长因子受体(EGFR)、雄激素受体(AR)、增殖细胞核抗原(Ki67)表达情况及临床指导意义。方法回顾性收集239例乳腺癌患者临床资料,均经病理学检查确诊,统计乳腺癌组织中不同临床病理特征CK5/6、EGFR、AR、Ki67阳性表达情况,采用Pearson相关分析CK5/6、EGFR、AR、Ki67表达情况与乳腺癌患者临床病理特征的相关性。结果乳腺癌组织中CK5/6、EGFR、AR、Ki67阳性表达率分别为15.90%、20.92%、90.38%、31.80%。Pearson相关分析显示,CK5/6与肿瘤直径呈正相关(r=0.64,P<0.05),EGFR、Ki67与肿瘤直径、组织学分级呈正相关(r分别=0.58、0.68、0.50、0.52,P均<0.05),EGFR与临床分期呈正相关(r=0.68,P<0.05),AR与组织学分级呈正相关(r=0.30,P<0.05),Ki67与淋巴结转移、临床分期呈正相关(r分别=0.48、0.49,P均<0.05)。结论随着乳腺癌患者病情进展可引起CK5/6、EGFR、AR、Ki67阳性表达升高,乳腺癌患者CK5/6、EGFR、AR、Ki67阳性表达情况与患者临床病理特征具有显著相关性,临床可通过检测乳腺癌患者CK5/6、EGFR、AR、Ki67阳性表达情况对患者病情进展程度进行评估。

Objective To investigate the expressions of cytokeratin 5/6(CK5/6),epidermal growth factor receptor(EGFR),androgen receptor(AR)and proliferating cell nuclear antigen(Ki67)in breast cancer patients with different clinicopathologic characteristics and their clinical significance.Methods Clinical data of 239 patients with breast can⁃cer were retrospectively collected,all of which were confirmed by pathological examination.The positive expressions of CK5/6,EGFR,AR and Ki67 in breast cancer tissues and different clinicopathological features were analyzed.Pearson correlation was used to analyze the correlations between CK5/6,EGFR,AR,Ki67 expressions and clinicopathologic fea⁃tures of breast cancer patients.Results The positive rates of CK5/6,EGFR,AR and Ki67 in breast cancer tissues were 15.90%,20.92%,90.38%and 31.80%,respectively.Pearson correlation analysis showed that CK5/6 was positively correlated with tumor diameter(r=0.64,P<0.05),EGFR and Ki67 were positively correlated with tumor diameter and histological grade(r=0.58,0.68,0.50,0.52,P<0.05).EGFR was positively correlated with clinical stage(r=0.68,P<0.05),AR was positively correlated with histological stage(r=0.30,P<0.05),Ki67 was positively correlated with lymph node metastasis and clinical stage(r=0.48,0.49,P<0.05).Conclusion With the progression of breast cancer patients,the positive expressions of CK5/6,EGFR,AR and Ki67 increase,and the positive expressions of CK5/6,EGFR,AR and Ki67 in breast cancer patients are significantly correlated with the clinicopathological features of pa⁃tients.The progression of the disease can be evaluated clinically by detecting positive expressions of CK5/6,EGFR,AR and Ki67 in breast cancer patients.