抵抗素样分子在血管重塑中的作用及机制研究进展

Advances in the role and mechanisms of resistin-like molecules in vascu⁃lar remodeling

心血管疾病是全世界致残和死亡的首要因素,心血管疾病常伴随血管结构的改变[1]。越来越多的证据表明,血管重塑是心血管疾病和其他致死性疾病的病理基础。血管重塑会导致血管闭塞、狭窄、硬化、扩张甚至破裂,从而使血管正常生理功能发生障碍,引起众多疾病的发生[2]。

Vascular remodeling is a prevalent pathological basis for many cardiovascular diseases.Therefore,understanding the regulatory mechanisms involved in vascular remodeling might provide insight into potential therapeutic targets and strategies for cardiovascular disease management.The family of resistin-like molecules(RELMs)consists mainly of four members in rodents such as RELMα/FIZZ1/HIMF,RELMβ/FIZZ2,resistin/FIZZ3,and RELMγ/FIZZ4.In humans,RELMs is composed of resistin and RELMβ.Notably,RELMs possess inflammatory regulating,chemokine,and growth factor properties and play an essential role in many pathophysiological processes.Recently,RELMs have been found to participate in vascular remodeling by regulating vascular cell proliferation,vascular smooth muscle cell phenotype transformation,extracellular matrix remodeling,angiogenesis,endothelial mesenchymal transformation,and inflammatory responses.The present paper reviews the role and mechanism of RELMs in vascular remodeling,aiming to provide a reference for the treatment of vascular remodeling-related diseases.