摘要
脑卒中又称中风,是一种发病突然的脑血液循环障碍性疾病,可分为缺血性脑卒中和出血性脑卒中,其中缺血性脑卒中发病率占87%,主要是由于局部脑组织血液供应障碍造成细胞缺血缺氧,引起组织坏死的一类具有破坏性的脑血管疾病[1]。缺血性脑卒中为全球第二大死因,其高发病率。
As an acute cerebrovascular disease,ischemic stroke is one of the leading causes of death and disability worldwide.It involves in fast developing and irreversible brain damage.Effective treatment is an important strategy to save patients'life and maintain their health.G protein-coupled estrogen receptor(GPER)mediates a rapid effect of estrogen,which can protect the nerves after ischemic brain injury.This review aims to summarize the multiple pathophysiological processes and signaling pathways of the involvement of GPER in cerebral ischemia,so as to provide theoretical reference for further study of the pathogenesis of ischemic stroke and new ideas for the development of drug targets.
作者
张梦杰
方世才
黄志华
ZHANG Mengjie;FANG Shicai;HUANG Zhihua(The Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Ministry of Education,Gannan Medical University,Ganzhou 341000,China;Department of Physiology,School of Basic Medical Sciences,Gannan Medical University,Ganzhou 341000,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2023年第6期1121-1126,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.31960190)
心脑血管疾病防治教育部重点实验室开放课题(No.XN201811)
江西省自然科学基金资助项目(No.20192BAB205117)
赣南医学院创新团队项目(No.TD201705)
江西省教育厅科学技术研究项目(No.GJJ2201427)
研究生创新专项资金项目(No.YC2021-S805)。
