肠道运动疾病与情绪异常共病发生的TRP通道机制

TRP channel mechanisms in the co-morbid occurrence of gut motility disorders and emotional abnormalities

肠道运动疾病与情绪异常共病是全球关注的健康问题。研究表明,瞬时受体电位(transient receptor potential,TRP)通道可调节肠道运动、菌群和稳态,并参与情绪的发生发展,其系统机制有待研究阐明。本文综合肠道运动障碍相关神经递质、激素、Ca^(2+)、肠道菌群与TRP通道的生理病理变化,相较于情绪异常相关的肠道运动与TRP通道,提出肠道运动疾病与情绪异常共病发生的TRP通道机制,以期为脑-肠与肠-脑系统稳态调控相关疾病的诊疗提供新思路。

Co-morbidity of gut motility disorders with mood abnormalities is a global health concern.Studies have shown that transient receptor potential(TRP)channels regulate intestinal motility,flora and homeostasis,and are involved in the development of mood,with systemic mechanisms to be elucidated.This paper integrates the physiopathological changes of neurotransmitters,hormones,Ca^(2+),intestinal flora and TRP channels related to intestinal motility disorders,and proposes a TRP channel mechanism for the co-morbidity of intestinal motility disorders and mood disorders,compared with the intestinal motility and TRP channels related to mood disorders,in order to provide new ideas for the diagnosis and treatment of homeostatic regulation of brain-gut and gut-brain systems.