胰腺微环境外泌体miRNA参与胰腺炎症和纤维化的发病机制研究进展

The research advance on the mechanism of the exosomal miRNA in pancreatic microenvironment in the pathogenesis of pancreatic inflammation and fibrosis

慢性胰腺炎(chronic pancreatitis,CP)发病率逐年上升,目前尚无明确根治性治疗方法且后期有进展为胰腺癌的风险。CP的典型病理学特征是胰腺慢性炎症和纤维化,CP进展与胰腺微环境中三种主要细胞(腺泡细胞、巨噬细胞以及胰腺星状细胞)间的相互作用密切相关,然而它们具体是如何进行细胞间联系的目前尚不清楚。新近研究表明外泌体作为细胞间重要的通讯介质,其携带的miRNA可通过调控主要细胞内基因表达和信号通路等影响CP的发生发展。本文围绕胰腺微环境中外泌体来源miRNA与三种主要细胞相互作用的机制,对其最新研究进展进行归纳和总结分析,以期为CP发病机制的深入认识提供参考。

The incidence of chronic pancreatitis(CP)is increasing year by year,and there is no curative treatment and a risk of developing pancreatic cancer in the later stage.The typical pathological features of CP are chronic inflammation and fibrosis of the pancreas.The development of CP is closely related to the three main intercellular interactions of acinar cell,macrophage and pancreatic stellate cell in the pancreatic microenvironment.But how exactly do they communicate between each other?Recent studies have shown that exosomes are important communication media between cells,and the miRNA they carry can affect the occurrence and development of CP by regulating intracellular gene expression and signaling pathways of the three major cells.In this paper,focusing on the mechanism of interaction between exosome-derived miRNA and the three main cells in the pancreatic microenvironment,the latest research progress was summarized and analyzed,in order to provide a reference for the in-depth understanding of the pathogenesis of CP.