《伤寒论》黄芩汤治疗溃疡性结肠炎作用机制研究进展

Research progress on the mechanism of Huangqin decoction in the treatment of ulcerative colitis

溃疡性结肠炎(ulcerative colitis,UC)属于慢性非特异性肠道炎症性病变(inflammatory bowel disease,IBD),具有反复发作、难以治愈的特点。由于目前溃疡性结肠炎的发病机制尚未完全清楚,所以现代医学手段对其治疗效果欠佳。且多年来,溃疡性结肠炎发病率呈现日益上升的发展趋势,故临床迫切需要探寻新的方法去干预该病。中医学中虽无溃疡性结肠炎这一病名,但参照其主要临床表现,可将其归属于“泄泻”“痢疾”等范畴。中医药防治此类病症由来已久,临床疗效卓著,治疗效果斐然,其中又以黄芩汤的治疗作用较为突显。且现代研究证明,不论是从动物实验、临床观察或是抗菌试验,黄芩汤均对溃疡性结肠炎的治疗卓有成效。随着关于黄芩汤治疗溃疡性结肠炎作用机制的研究越来越多,诸多实验证明黄芩汤治疗溃疡性结肠炎多与免疫细胞、细胞因子及相关信号通路、肠道菌群以及细胞焦亡等途径相关。本文将对黄芩汤治疗溃疡性结肠炎的作用机制就以上方面进行综述,以期为日后实验或临床应用黄芩汤提供参考依据。

Ulcerative colitis(UC)belongs to intestinal inflammatory disease(IBD),which has the characteristics of recurrent and difficult to cure.The pathogenesis of ulcerative colitis is not yet fully understood,modern medical methods are not effective in its treatment.And over the years,people's living habits have undergone tremendous changes,and the incidence of UC has shown an increasing trend.There is an urgent need to explore new ways to intervene in this disease.Although there is no name for UC in traditional Chinese medicine,it can be classified as“diarrhea,dysentery”and other diseases with reference to its main clinical manifestations.Traditional Chinese medicine has a long history of preventing and treating such diseases,with outstanding clinical curative effect and remarkable therapeutic effect.Among them,the therapeutic effect of the prescription Huangqin Decoction is more prominent.And modern research has proved that,whether from animal experiments,clinical observations or antibacterial tests,Huangqin Decoction is effective in the treatment of UC.with more and more studies on the mechanism of Huangqin Decoction in the treatment of UC,many experiments have proved that the treatment of ulcerative colitis by Huangqin Decoction is mostly related to immune cells,cytokines and related signaling pathways,intestinal flora and cell coke death.This article will review the mechanism of Huangqin Decoction in the treatment of UC in the above aspects,in order to provide references for future experimental or clinical application of Huangqin Decoction.