摘要
改进杀菌剂氟吡菌酰胺中间体3-氯-2-氨乙基-5-三氟甲基吡啶的合成工艺。以3-氯-2-氰甲基-5-三氟甲基吡啶为原料,在雷尼镍和水合肼体系下催化加氢还原得到3-氯-2-氨乙基-5-三氟甲基吡啶。后将其转化为盐酸盐,达到纯化的目的。该工艺反应条件温和,操作简单,适合工业化生产。催化剂可套用。
This study aims to improve the process for the preparation of 3-chloro-2-(2-aminoethyl)-5-(trifluoromethyl)pyridine which is an intermediate for the synthesis of fluopyram.The 3-chloro-2-(2-cyanomethyl)-5-(trifluoromethyl)pyridine is catalytically hydrogenated by Raney nickel and hydrazine monohydrate into the 3-chloro-2-(2-aminoethyl)-5-(trifluoromethyl)pyridine.Then is subjected to 3-chloro-2-(2-aminoethyl)-5-(trifluoromethyl)pyridine hydrochloride which is high purity.This process is simple,warm and economical,which is suitable for industrial scale manufacture.The catalyst can be recycled.
作者
赵宏伟
ZHAO Hongwei(CAC Nantong Chemical Co.,Ltd.,Shanghai 201612,China)
出处
《世界农药》
CAS
2023年第6期30-33,共4页
World Pesticide