急性髓系白血病骨髓微环境中T细胞免疫稳态的预后和治疗价值探讨

The prognostic and therapeutic value of T cell immune homeostasis in the bone marrow microenvironment of acute myeloid leukemia

骨髓微环境(bone marrow microenvironment, BMM)在急性髓系白血病(acute myeloid leukemia, AML)的发生、发展中扮演着重要角色。研究表明,T细胞在正常BMM中具有维持免疫稳态、促进造血干细胞分化平衡的作用,而在AML状态下,BMM中的T细胞免疫稳态遭到破坏,呈现失衡状态,这提示BMM中T细胞免疫稳态失衡参与了AML的发生、发展过程。然而,目前关于AML患者BMM中T细胞免疫稳态失衡的特点以及这种失衡状态在患者预后判断和治疗中的价值尚未被充分认识。该文从T细胞在正常骨髓生态中的作用进行切入,进一步探讨BMM中的T细胞免疫稳态失衡对AML预后预测以及治疗的潜在价值。

The bone marrow microenvironment(BMM)plays an important role in the development of acute myeloid leukemia(AML).Multiple studies have shown that T cells can maintain immune homeostasis and promote the differentiation balance of hematopoietic stem cells in normal BMM.However,the immune homeostasis of T cells in BMM is disrupted and unbalanced in AML,suggesting that the imbalanced BMM T cell state may be involved in the development of AML.The characteristics of BMM T cell homeostasis imbalance and the value of the imbalance in the prognosis and treatment of AML patients have not been fully understood.This review outlines the role of T cells in the normal bone marrow and the potential value of BMM T cell immune homeostasis in prognosis prediction and treatment of AML patients.