丙泊酚抗心肌缺血/再灌注损伤相关机制的研究进展

Research progress on related mechanisms of propofol against myocardial ischemia-reperfusion injury

由于我国心血管疾病发病率处于持续上升阶段,伴发心脏病接受心脏或非心脏手术的患者数量逐年增多,而心肌缺血/再灌注损伤(MIRI)的发生不仅严重影响患者预后,还造成了巨大的经济负担。丙泊酚是临床应用最广泛的静脉全身麻醉药物之一,自诞生以来,其对于器官和组织的保护作用一直受到国内外众多研究者的关注。目前,许多研究发现丙泊酚可能通过抗氧化应激、减少钙超载、抑制线粒体通透性转换、抗炎、抑制铁死亡、减轻心肌细胞自噬、抑制肥大细胞的活化、影响长链非编码RNA和微小RNA的表达等相关机制从而减轻MIRI。该文针对丙泊酚抗MIRI的相关机制,尤其是近年来的研究发现进行总结,为后续的相关研究提供参考。

As the incidence rate of cardiovascular disease continues to rise in China,the number of the patients with complicating heart disease receiving cardiac or non-cardiac surgery is increasing year by year,the occurrence of myocardial ischemia/reperfusion injury(MIRI)seriously affects the prognosis of the patients and causes the huge economic burden.Propofol is one of the most widely used intravenous general anesthesia drugs in clinic.Since its birth,its protective effect on organs or tissues attracts the attention of researchers from both at home and abroad.At present,many studies find that propofol may alleviate MIRI through related mechanisms such as antioxidant stress,reducing calcium overload,inhibiting mitochondrial permeability transition,anti-inflammatory,inhibiting iron death,reducing autophagy of cardiomyocytes,inhibiting mast cell activation and affecting the expression of lncRNA and miRNA.This review summarizes the anti-MIRi mechanism of propofol,especially the research findings in recent years,to provide reference for subsequent relevant studies.