重组人脑利钠肽与硝普钠治疗急性心力衰竭的疗效、心功能及血流动力学指标对比

Comparison of the Efficacy,Cardiac Function,and Hemodynamic Indexes of Recombinant Human Brain Natriuretic Peptide and Sodium Nitroprusside in the Treatment of Acute Heart Failure

目的探究重组人脑利钠肽(rhBNP)与硝普钠(SNP)治疗急性心力衰竭(AHF)的疗效、心功能及血流动力学指标的区别。方法选取2018年10月至2020年10月新里程安钢总医院收治的105例AHF患者纳入研究,根据给予治疗方法的不同分为研究组(63例)与对照组(42例),研究组给予rhBNP,对照组给予SNP,比较两组患者治疗后的临床疗效、心功能指标[左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、左室收缩末期内径(LVESD)]、血流动力学参数[血氧饱和度(SpO_(2))、中心静脉压(CVP)、舒张末期流速(EDFV)、收缩期峰值流速(PSFV)]及用药安全性。结果研究组治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组心功能、血流动力学水平比较,差异无统计学意义(P>0.05);治疗后,两组LVEDD、LVESD、CVP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组LVEF、SpO_(2)、EDFV、PSFV均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论rhBNP治疗AHF相较于SNP能提高患者治疗有效率,改善心功能指标及血流动力学指标,且用药安全性高。

Objective To investigate the efficacy,cardiac function,and hemodynamic parameters of recombinant human brain natriuretic peptide(rhBNP)and sodium nitroprusside(SNP)in the treatment of acute heart failure(AHF).Methods A total of 105 patients with AHF admitted to Xinlicheng Angang General Hospital from October 2018 to October 2020 were included in the study.According to the different treatment methods,they were divided into the study group(63 cases)and the control group(42 cases).The study group was given rhBNP and the control group was given SNP.The clinical efficacy,cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)],hemodynamic parameters[blood oxygen saturation(SpO_(2)),central venous pressure(CVP),end-diastolic flow velocity(EDFV),peak systolic flow velocity(PSFV)]and drug safety were compared between the two groups after treatment.Results The treatment effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in cardiac function and hemodynamics between the two groups(P>0.05).After treatment,the levels of LVEDD,LVESD,and CVP in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,LVEF,SpO_(2),EDFV,and PSFV in the two groups were higher than those before treatment,and those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in ADR between the two groups(P>0.05).Conclusion Compared with SNP,rhBNP in the treatment of AHF can improve the effective rate,cardiac function,and hemodynamic indexes,and has high safety.