唑来膦酸、化疗联合多维度协同管理治疗非小细胞肺癌骨转移的疗效及对患者的影响

Influence of Zoledronic Acid,Chemotherapy and Multi-dimensional Collaborative Management on the Treatment Effects for Non-small Cell Lung Cancer Patients with Osseous Metastasis

目的观察非小细胞肺癌骨转移患者予以多维度协同管理和化疗、唑来膦酸联合干预对其生活质量、疼痛程度、临床效果的影响。方法临床纳入2021年7月至2022年7月河南大学第一附属医院收治的80例非小细胞肺癌骨转移患者,根据随机双盲法分组,分为对照组、研究组,每组均为40例,研究组予以多维度协同管理和化疗、唑来膦酸联合干预,对照组予以多维度协同管理和化疗干预。应用肿瘤患者生存治疗量表分析评估(QLQ-C30)分析两组的生活质量;分析两组的临床效果、心理状况、生活质量、不良反应。结果研究组的临床治疗效果优于对照组,差异有统计学意义(P<0.05)。干预后两组不良心理状态(抑郁、焦虑)指标评分低于干预前,且研究组不良心理(抑郁、焦虑)指标评分低于对照组,差异有统计学意义(P<0.05)。干预后两组肿瘤患者QLQ-C30评分指标均高于干预前,且研究组肿瘤患者QLQ-C30评分指标高于对照组,差异有统计学意义(P<0.05)。治疗后两组不良反应(皮疹、肌痛、发热、恶心呕吐)发生情况比较,差异无统计学意义(P>0.05)。结论非小细胞肺癌骨转移予以多维度协同管理联合化疗、唑来膦酸联合干预可提高患者的心理状态,治疗效果显著,治疗安全性较高,可提高其生活质量,值得临床应用。

Objective To observe the influence of multi-dimensional collaborative management,chemotherapy and zoledronic acid on the life quality,pain degree and treatment effects for non-small cell lung cancer patients with osseous metastasis.Methods A total of 80 non-small cell lung cancer patients with osseous metastasis treated from July 2021 to July 2022 in the First Affiliated Hospital of Henan University were selected.According to random double-blind method,patients were divided into control group and study group,with 40 cases in each group.The study group was given multi-dimensional collaborative management and combined intervention of chemotherapy and zoledronic acid,while the control group was given multi-dimensional collaborative management and chemotherapy intervention.Patient’s life quality was appraised through the quality of life questionnaire core 30(QLQ-C30).Analyze the clinical effects,psychological status,life quality,and adverse reactions of the two groups.Results The clinical effects in the study group were better than control group,with statistically significant difference(P<0.05);after intervention,the adverse mental state scores of depression and anxiety for two groups were remarkably decreased;the adverse mental state scores in the study group were even lower than control group,with statistically significant difference(P<0.05);after treatment,QLQ-C30 scores of social function,emotional function,cognitive function,role physical and physical function for two groups were remarkably increased;QLQ-C30 scores of social function,emotional function,cognitive function,role physical and physical function in the study group were even higher than control group,with statistically significant difference(P<0.05);the incidences of adverse reactions like skin rash,myalgia,fever,nausea and vomiting in the study group were lower than control group,with statistically significant difference(P<0.05).Conclusion The multi-dimensional collaborative management,chemotherapy and zoledronic acid can effectively improve the mental states,treatment effects and safety,and life quality for nonsmall cell lung cancer patients with osseous metastasis.It is worthy of clinical promotion and application.