开喉剑喷雾剂联合干扰素α1b雾化治疗小儿疱疹性咽峡炎的疗效及对血清炎性因子水平的影响

Effect of Kaihoujian Spray combined with interferon α1b atomization on children with herpetic angina and its effect on serum inflammatory factors

目的分析开喉剑喷雾剂加干扰素α1b雾化用于疱疹性咽峡炎患儿的效果和对炎性因子的影响。方法选取2020年2月至2022年2月洛阳石化医院收治的82例疱疹性咽峡炎患儿,经随机数字表法将其中41例归纳到对照组(通过雾化途径使用干扰素α1b),余下41例归纳到观察组(除前组治疗外加以开喉剑喷雾剂)。观察两组疗效,治疗前后症状积分、血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)水平,副反应出现情况。结果观察组治疗有效率(97.56%)高于对照组(80.49%),差异有统计学意义(P<0.05)。治疗前,两组症状积分(咽痛、发热、疱疹、流涎、拒食及精神差)比较,差异无统计学意义(P>0.05);治疗后,观察组症状积分低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清中IL-2、IL-6、CRP、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,观察组各项炎性因子水平低于对照组,差异有统计学意义(P<0.05)。两组副反应(皮疹、恶心及嗜睡)发生情况比较,差异无统计学意义(P>0.05)。结论开喉剑喷雾剂加干扰素α1b雾化用于疱疹性咽峡炎患儿疗效理想,能改善其各项症状,降低其炎性因子水平,同时不会显著增加副反应产生,安全性高。

Objective To analyze the effect of Kailyjian spray plus interferon α1b aerosol on children with herpetic angina and its effect on inflammatory factors.Methods A total of 82 children with herpangina admitted to Luoyang Petrochemical Hospital from February 2020 to February 2022 were selected.Among them,41 cases were divided into the control group(interferon α1b was used by atomization route),and the remaining 41 cases were divided into the observation group(in addition to the treatment of the former group,the kaihoujian spray was used).The efficacy,symptom score,serum levels of interleukin-2(IL-2),interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)before and after treatment,and the occurrence of side effects of the two groups were observed.Results The effective rate of the observation group(97.56%)was higher than that of the control group(80.49%),the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in symptom scores(pharyngeal pain,fever,herpes,salivation,anti-feeding and poor spirit)between the two groups(P>0.05).After treatment,the symptom score of the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum levels of IL-2,IL-6,CRP,and TNF-α between the two groups(P>0.05).After treatment,the levels of inflammatory factors in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the occurrence of side effects(rash,nausea,and lethargy)between the two groups(P>0.05).Conclusion Kaihoujian spray plus interferonα1b atomization has an ideal therapeutic effect on children with herpetic angina,which can improve the symptoms and reduce the level of inflammatory factors without significantly increasing the occurrence of side effects.It is safe and worthy of use.