血管介入联合常规抗凝、抗血小板治疗急性脑梗死患者的效果

Effects of vascular intervention combined with conventional anticoagulation and antiplatelet therapy on patients with acute cerebral infarction

目的:观察血管介入联合常规抗凝、抗血小板治疗急性脑梗死患者的效果。方法:选取2019年1月至2021年7月80例急性脑梗死患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各40例。对照组给予常规抗凝、抗血小板治疗,研究组在对照组基础上给予血管介入治疗,比较两组疗效、美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分和血浆纤溶系统指标[血管性假血友病因子(vWF)、组织型纤溶酶原激活物(tPA)、纤溶酶原激活物抑制剂-1(PAI-1)]水平。结果:研究组治疗总有效率为92.50%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);治疗后,研究组NIHSS评分和血浆PAI-1、vWF水平低于对照组,GCS评分和血浆tPA水平高于对照组,差异均有统计学意义(P<0.05)。结论:血管介入联合常规抗凝、抗血小板治疗急性脑梗死患者可提高疗效和GCS评分,降低NIHSS评分,改善血浆纤溶系统指标水平,效果优于单纯常规抗凝、抗血小板治疗。

Objective:To observe effects of vascular intervention combined with conventional anticoagulation and antiplatelet therapy on patients with acute cerebral infarction.Methods:A prospective study was conducted on 80 patients with acute cerebral infarction from January 2019 to July 2021.They were divided into study group and control group according to random number table method,40 cases in each group.The control group was given conventional anticoagulation and antiplatelet therapy,while the study group was given vascular interventional therapy on the basis of that of the control group.The efficacy,the National Institutes of Health stroke scale(NIHSS)score,the Glasgow coma scale(GCS)score,and the plasma fibrinolytic system indexes levels[von Willebrand factor(vWF),tissue plasminogen activator(tPA),plasminogen activator inhibitor-1(PAI-1)]were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.50%,which was significantly higher than 75.00% in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score and the plasma PAI-1 and vWF levels in the study group were lower than those in the control group;the GCS score and plasma tPA level were higher than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Vascular intervention combined with conventional anticoagulation and antiplatelet therapy for the patients with acute cerebral infarction can improve the efficacy and the GCS scores,reduce NIHSS scores,and improve the levels of plasma fibrinolytic system.Moreover,it is superior to single conventional anticoagulation and antiplatelet therapy.