达格列净联合胰岛素泵短期强化治疗2型糖尿病患者的效果

Effects of Dapagliflozin combined with short-term intensive treatment of insulin pump on patients with type 2 diabetes

目的:观察达格列净联合胰岛素泵短期强化治疗2型糖尿病患者的效果。方法:选取2020年5月至2022年2月该院收治的110例2型糖尿病患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各55例。对照组给予胰岛素泵短期强化治疗,观察组在对照组基础上联合达格列净片治疗,比较两组血糖[空腹血糖(FBG)、餐后2 h血糖(2hPG)]水平、血脂[高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、总胆固醇(TC)]水平、住院时间、空腹胰岛素(FINS)水平、胰岛素分泌指数(HOMA-β)水平和不良反应发生率。结果:治疗后,两组FBG、2hPG、TC、TG水平均低于治疗前,且观察组低于对照组,两组HDL-C水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组住院时间短于对照组,差异有统计学意义(P<0.05);治疗后,两组FINS、HOMA-β水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:达格列净联合胰岛素泵短期强化治疗2型糖尿病患者可提高FINS水平和HOMA-β水平,缩短住院时间,改善血脂水平,以及降低血糖水平,效果优于单纯胰岛素泵短期强化治疗。

Objective:To observe effects of Dapagliflozin combined with short-term intensive treatment of insulin pump on patients with type 2 diabetes.Methods:A prospective study was conducted on 110 patients with type 2 diabetes admitted to the hospital from May 2020 to February 2022.They were divided into observation group and control group according to the random number table method,55 cases in each group.The control group was given short-term intensive treatment of insulin pump,while the observation group was treated with Dapagliflozin tablets on the basis of that of the control group.The levels of blood glucose[fasting blood glucose(FBG),2 h postprandial blood glucose(2hPG)]and blood lipid[high density lipoprotein cholesterol(HDL-C),triglyceride(TG),total cholesterol(TC)],the hospitalization time,the fasting insulin(FINS)level,the insulin secretion index(HOMA-β),and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the levels of FBG,2hPG,TC and TG in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the HDL-C levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).The hospitalization time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FINS and HOMA-βin the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dapagliflozin combined with short-term intensive treatment of insulin pump for the type 2 diabetic patients can improve FINS levels and HOMA-βlevels,shorten their hospitalization time,improve the blood lipid levels,and reduce the blood glucose levels.Moreover,it is superior to single short-term intensive treatment of insulin pump.