高压氧联合氟哌噻吨美利曲辛片治疗卒中后睡眠障碍患者的效果

Effects of hyperbaric oxygen combined with Flupentixol and Melitracen tablets in treatment of patients with post-stroke sleep disorders

目的:观察高压氧联合氟哌噻吨美利曲辛片治疗卒中后睡眠障碍患者的效果。方法:回顾性分析2020年1月至2021年4月该院收治的177例卒中后睡眠障碍患者的临床资料,根据治疗方式不同将其分为研究组(n=89)与对照组(n=88)。对照组采取氟哌噻吨美利曲辛片治疗,研究组在对照组基础上给予高压氧治疗,比较两组临床疗效、治疗前后睡眠质量[匹兹堡睡眠质量指数量表(PSQI)、爱泼沃斯嗜睡量表(ESS)]评分、脑血流灌注指标[脑血容量(CBV)、脑血流量(CBF)、对比剂达峰时间(TTP)]水平和不良反应发生率。结果:研究组治疗总有效率为95.51%(85/89),高于对照组的79.55%(70/88),差异有统计学意义(P<0.05);治疗后,两组PSQI、ESS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CBV、CBF水平均高于治疗前,且研究组高于对照组,两组TTP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:高压氧联合氟哌噻吨美利曲辛片治疗卒中后睡眠障碍患者可提高治疗总有效率,改善脑血流灌注指标水平,降低PSQI和ESS评分,效果优于单纯氟哌噻吨美利曲辛片治疗。

Objective:To observe effects of hyperbaric oxygen combined with Flupentixol and Melitracen tablets treatment of patients with post-stroke sleep disorders.Methods:The clinical data of 177 patients with post-stroke sleep disorders admitted to this hospital from January 2020 to April 2021 were retrospectively analyzed.They were divided into study group(n=89)and control group(n=88)according to different treatment methods.The control group was treated with Flupentixol and Melitracen tablets,while the study group was treated with hyperbaric oxygen on the basis of that of the control group.The clinical efficacy,the sleep quality[Pittsburgh sleep quality index(PSQI),the Epworth sleepiness scale(ESS)]score before and after the treatment,the cerebral blood flow perfusion index levels[cerebral blood volume(CBV),cerebral blood flow(CBF),contrast peak time(TTP)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.51%(85/89),which was higher than 79.55%(70/88)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the PSQI and ESS scores of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CBV and CBF in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the TTP levels of the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Hyperbaric oxygen combined with Flupentixol and Melitracen tablets in the treatment of the patients with post-stroke sleep disorders can improve the total effective rate of treatment,improve the levels of cerebral blood perfusion indexes,and reduce the PSQI and ESS scores.Moreover,it is superior to single Flupentixol and Melitracen tablets treatment.