丹润面膜联合氨甲环酸治疗黄褐斑肝郁气滞证30例

Clinical effect of Danrun facial mask combined with tranexamic acid in treatment of chloasma with liver Qi stagnation syndrome:An analysis of 30 cases

目的:观察丹润面膜联合氨甲环酸治疗黄褐斑肝郁气滞证的临床疗效。方法:将60例女性黄褐斑肝郁气滞证患者随机分为治疗组和对照组,每组各30例。对照组予以口服氨甲环酸治疗,治疗组在对照组的基础上联合丹润面膜治疗。观察2组治疗前后皮损总评分、复发率,评价综合疗效。结果:对照组脱落1例。总有效率治疗组为96.67%(29/30),对照组为93.10%(27/29),2组差异有统计学意义(P<0.05);2组治疗后皮损总评分均较治疗前明显降低,且治疗组降低幅度大于对照组,差异均有统计学意义(P<0.01);治疗结束后3个月,复发率治疗组为13.64%(3/22),对照组为54.55%(6/11),差异有统计学意义(P<0.05)。结论:丹润面膜联合氨甲环酸能够改善黄褐斑皮损症状,提高临床疗效。

Objective:To investigate the clinical effect of Danrun facial mask combined with tranexamic acid in the treatment of chloasma with liver Qi stagnation syndrome.Methods:A total of 60 patients with female chloasma with liver Qi stagnation syndrome were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group were given oral administration of tranexamic acid,and those in the treatment group were given Danrun facial mask in addition to the treatment in the control group.The two groups were observed in terms of total skin lesion score and recurrence rate before and after treatment,and overall response was evaluated.Results:One patient in the control group was lost to follow-up.There was a significant difference in overall response rate between the treatment group and the control group[96.67%(29/30)vs 93.10%(27/29),P<0.05].Both groups had a significant reduction in total skin lesion score after treatment,and the treatment group had a signifi-cantly greater reduction than the control group(P<0.01).At 3 months after the treatment ended,there was a signifi-cant difference in recurrence rate between the treatment group and the control group[13.64%(3/22)vs 54.55%(6/11),P<0.05].Conclusion:Danrun facial mask combined with tranexamic acid can improve the symptom of skin lesion due to chloasma and the clinical outcome of patients.