前列地尔治疗高龄糖尿病并慢性肾脏病患者的临床效果和安全性探讨

Clinical efficacy and safety of alprostadil in the treatment of elderly patients with diabetes mellitus and chronic kidney disease

目的 研究前列地尔治疗高龄糖尿病并慢性肾脏病患者的临床效果和安全性。方法 200例高龄糖尿病并慢性肾脏病患者,随机分为实验组和对照组,各100例。对照组接受常规治疗,实验组在对照组基础上使用前列地尔治疗。比较两组临床效果、肾功能指标[血清尿素氮(SUN)、血清肌酐(SCr)、24 h尿微量白蛋白定量(24 h UMALB)、24 h尿白蛋白排泄率(24 h UAER)]、不良反应发生情况。结果 实验组治疗总有效率99.00%高于对照组的86.00%,差异有统计学意义(P<0.05)。实验组SUN(6.55±1.12)mmol/L、SCr(90.45±18.22)μmol/L、24 h UMALB(369.12±29.64)mg/d、24 h UAER(1.23±0.31)g/d低于对照组的(7.57±2.02)mmol/L、(108.56±19.58)μmol/L、(408.54±25.46)mg/d、(1.99±0.44)g/d,差异有统计学意义(P<0.05)。实验组不良反应发生率2.00%低于对照组的9.00%,差异有统计学意义(P<0.05)。结论 前列地尔治疗高龄糖尿病并慢性肾脏病患者具有显著疗效,可改善患者的肾功能,提升疗效,该治疗模式可推广。

Objective To study the clinical effect and safety of alprostadil in the treatment of elderly patients with diabetes mellitus and chronic kidney disease.Methods A total of 200 elderly patients with diabetes mellitus and chronic kidney disease were randomly divided into experimental group and control group,with 100 cases in each group.The control group was treated with conventional treatment,and the experimental group was treated with alprostadil on the basis of the control group.Both groups were compared in terms of clinical effects,renal function indexes[serum urea nitrogen(SUN),serum creatinine(SCr),24 h urinary microalbumin(24 h UMALB),24 h urinary albumin excretion rate(24 h UAER)],and the occurrence of adverse reactions.Results The total effective rate of the experimental group was 99.00%,which was higher than that of 86.00%of the control group,and the difference was statistically significant(P<0.05).The experimental group had SUN of(6.55±1.12)mmol/L,SCr of(90.45±18.22)μmol/L,24 h UMALB of(369.12±29.64)mg/d,and 24 h UAER of(1.23±0.31)g/d,which were lower than those of(7.57±2.02)mmol/L,(108.56±19.58)μmol/L,(408.54±25.46)mg/d,and(1.99±0.44)g/d in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 2.00%,which was lower than that of 9.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Alprostadil is effective in the treatment of elderly patients with diabetes mellitus and chronic kidney disease,which can improve the renal function of patients and improve the therapeutic effect.It is worthy of promotion.