RBP2在肿瘤中的作用及其选择性抑制剂的研究进展

The role of RBP2 and its selective inhibitors in tumor

视黄醇结合蛋白2(retinol-binding protein 2,RBP2)可特异性去除组蛋白H3第4位赖氨酸上的二甲基和三甲基,从而介导基因沉默和调节细胞功能。多项研究表明RBP2与肿瘤的关系密切,它不仅有助于肿瘤细胞的分化、代谢和增殖,还可以阻遏肿瘤细胞抑制基因的表达,诱发肿瘤细胞的侵袭和转移,促进耐药的发生。因此,RBP2可成为肿瘤诊断和治疗的新靶点之一。针对RBP2的选择性抑制剂的探讨将有助于我们对其结构、功能及生物学作用的认识,并有望开发出新的抗癌药物。

Retinol-binding protein 2(RBP2)can mediate gene silencing and regulate cell function through removing dimethyl and trimethyl from the fourth lysine of histone H3 specifically.Many studies have shown that RBP2 is closely related to tumor.It not only contributes to the differentiation,metabolism and proliferation of tumor cells,but also inhibits the expression of suppressor genes of tumor cells,induces tumor cell invasion and metastasis,and promotes the occurrence of drug resistance.Therefore,RBP2 can become one of the new targets for tumor diagnosis and treatment.The study of selective inhibitors of RBP2 will help us to understand its structure,function and biological function,and contributes to develop new anticancer drugs.