合成生物学和肿瘤治疗

Synthetic biology and cancer therapy

合成生物学通过发现、认识和重构分子部件来编辑新的生物学功能,其合成的细菌、基因线路、蛋白质和糖类、核酸、病毒以及多细胞,现在已经用于肿瘤的细菌治疗、细胞治疗和肿瘤疫苗等临床领域。未来合成生物学可能带来全新的多功能蛋白质、代谢通路和多细胞结构,这将改变现有的肿瘤治疗模式。

Synthetic biology is a discipline centered on engineering novel biological functions through the discovery,characterization,and repurposing of molecular parts.The applications of synthetic biology for cancer include bacterial therapeutics,cell-based therapeutics,and vaccine development based on synthetic bacteria,gene circuits,proteins and carbohydrate,nucleic acid,virus or cells.Synthetics biology will take the form of evolved multifunctional proteins,metabolic pathways,or multicellular consortia,and may change the current cancer treatment modality.