摘要
以价廉、易得的石墨片为原料,采用改进的Hummers法,简单、快速、高效地制备了具有良好生物相容性的橙色荧光氧化石墨烯量子点(GOQDs)。所制备的GOQDs尺寸约7.2 nm,具有尺寸均匀、晶格间距为0.20 nm的高度结晶的核心和氧化的外围结构。与大多数报道的碳点(CDs)、包裹掺杂碳点(掺杂CDs)、石墨烯量子点(QDS)和GOQDs不同,我们的方法制备的GOQDs显示出橙红色并具有激发波长独立的荧光发射。此外,GOQDs具有pH依赖性荧光发射、强的光漂白抗性、低细胞毒性、良好的水溶性(ρ=10 mg·mL^(-1))和优异的生物相容性。这些特性使其成功应用于细胞pH成像。
A simple,quick,and efficient chemical oxidation technique was employed to fabricate excellent biocompatible orange fluorescence graphene oxide quantum dots(GOQDs)with affordable,widely available graphite flake as the raw material.The as-prepared GOQDs have uniform sizes of ca.7.2 nm,highly crystallized core with a lattice spacing of 0.20 nm,and oxidized peripherals.Unlike most reported doped-carbon dots,the GOQDs displayed orangered independent fluorescent emission when the excitation wavelength was changed.The pH dependence emission,strong resistance of photobleaching,low cytotoxicity,good water solubility(ρ=10 mg·mL^(-1)),and excellent biocompatibility behaviors made GOQDs successfully applied to live cell pH fluctuation imaging.
作者
王鸿锦
尹桂
WANG Hong-Jin;YIN Gui(College of Chemistry and Environmental Science,Yili Normal University,Yining,Xinjiang 835000,China;State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China)
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2023年第7期1338-1348,共11页
Chinese Journal of Inorganic Chemistry
基金
supported by the State Key Laboratory of Analytical Chemistry for Life Science,Jiangsu Key Laboratory of Advanced Organic Materials,School of Chemistry and Chemical Engineering,Nanjing University。