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肺淋巴管功能及其在肺部疾病的研究进展

Pulmonary lymphatic function and its research progress in pulmonary diseases
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摘要 淋巴管系统是一个单向网络,淋巴液沿着一系列的淋巴管道向心流动,最终汇入静脉,因此淋巴系统也可以认为是静脉系统的辅助部分,是心血管系统的重要组成部分。淋巴管系统负责调节组织液的平衡、脂质吸收及免疫监测等功能,其失调会导致多种疾病。肺淋巴管系统在多种肺部疾病中扮演着非常重要的角色,涉及维持体液平衡,抗原呈递等,此外还会影响到肺移植后移植体的存活等。本文针对肺淋巴管以及其在肺部疾病中的作用进行介绍。 The lymphatic system is a unidirectional network in which lymph fluid flows centripetally along a series of lymphatic channels and eventually into the veins,so the lymphatic system can also be considered an auxiliary part of the venous system and an important part of the cardiovascular system.The lymphatic system,which regulates interstitial fluid balance,lipid absorption,and immune monitoring,and its imbalance can lead to a variety of diseases.The pulmonary lymphatic system plays a very important role in many lung diseases,involving maintaining fluid balance,antigen presentation,etc.,in addition,it will affect the survival of the transplant after lung transplantation.This article focuses on pulmonary lymphatic vessels and their role in lung disease.
作者 康旭雅 方冉 张岩 刘雅涵 董尔丹 Kang Xuya;Fang Ran;Zhang Yan;Liu Yahan;Dong Erdan(Institute of Cardiovascular Sciences,Peking University,Beijing 100191,China;State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing 100191,China;Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Beijing Key Laboratory of Cardiovascular Receptors Research,Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases,Chinese Academy of Medical Sciences,Beijing 100191,China;Research Center of Population Health and Social Development,University of Health and Rehabilitation Sciences/Soft Science Research Base of Public Policy on Population Health in Shandong Province,Qingdao 266071,Shandong,China)
出处 《生物医学转化》 2023年第2期50-56,共7页 Biomedical transformation
基金 国家自然科学基金重大研究计划培育项目(92168113) 中国医学科学院医学与健康科技创新工程项目(2021-I2M-5-003) 国家自然科学基金面上项目(82170422) 北京大学医学青年科技创新平台医学交叉种子基金项目(BMU2022MX013) 北京市自然科学基金面上项目(7232096)。
关键词 淋巴内皮 淋巴管瓣膜 淋巴管发生 肺淋巴管 肺部疾病 Lymphatic endothelium Lymphatic valve Lymphangiogenesis Pulmonary lymphatic vessels Pulmonary disease
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