胰高血糖素样肽-1在抑郁症中的作用及机制

Role and mechanism of glucagon-like peptide-1 in depression

胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种肠促胰岛素激素和肠脑轴的主要激素,与能量稳态的控制和肥胖的发生有关。除了抑制食欲外,GLP-1还作用于大脑中与压力反应和情绪调节有关的区域,具有神经保护作用。抑郁症是常见的精神类疾病,GLP-1与抑郁症关系密切。该文将对GLP-1在抑郁症中的作用及机制进行综述。

Glucagon-like peptide-1(GLP-1)is a major hormone of incretin hormone and gut-brain axis,which is related to the control of energy homeostasis and the occurrence of obesity.In addition to suppressing appetite,GLP-1 has neuroprotective effects by acting on areas of the brain involved in stress response and mood regulation.Depression is a common mental disease,and GLP-1 is closely related to depression.This article reviews the role and mechanism of GLP-1 in depression.