银杏二萜内酯葡胺联合尤瑞克林治疗急性脑梗死的临床疗效

The clinical efficacy of ginkgo biloba diterpenoid lactone glucosamine combined with urinary kallidinogenase in the treatment of acute cerebral infarction

目的 探讨银杏二萜内酯葡胺联合尤瑞克林治疗急性脑梗死(acute cerebral infarction, ACI)的临床疗效。方法 将84例ACI患者分为观察组与对照组,每组42例。两组均予尤瑞克林治疗,观察组另予银杏二萜内酯葡胺治疗。比较两组治疗前后血流动力学指标,包括平均血流速度(mean blood flow velocity, MBFV)、椎动脉血流量(vertebral artery blood flow, VABF)、基底动脉血流量(basilar artery blood flow, BABF),神经功能指标,包括神经元特异性烯醇化酶(neuron specific enolase, NSE)、同型半胱氨酸(homocysteine, Hcy)、中枢神经特异蛋白(S100-β)和美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)评分,以及炎性因子指标,包括超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β),观察两组临床疗效和不良反应发生情况。结果 观察组治疗总有效率较对照组高(95.24%vs.80.95%, P=0.043);治疗后观察组MBFV、VABF及BABF均高于对照组,NSE、Hcy、S100-β水平及NIHSS评分均较对照组低(P <0.001),hs-CRP、IL-6及IL-1β水平均较对照组低(P <0.001);治疗2周后两组患者颜面潮红、乏力、心悸、皮疹及胃肠道不适等不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 银杏二萜内酯葡胺联合尤瑞克林治疗ACI患者有助于改善血流动力学和神经功能,抑制炎症反应。

Objective To explore the clinical efficacy of ginkgo biloba diterpenoid lactone glucosamine combined with urinary kallidinogenase in the treatment of acute cerebral infarction.Method 84 patients with ACI were randomly divided into the observation group and the control group,with 42 patients in each group.Both groups were treated with urinary kallidinogenase,but the observation group was treated with ginkgo diterpene lactone glucosamine on the basis of the control group.The hemodynamics,including mean blood flow velocity(MBFV),vertebral artery blood flow(VABF)and basilar artery blood flow(BABF),neurological function,including scores of neuron specific enolase(NSE),homocysteine(Hcy),central nerve specific protein(S100-β)and National Institutes of Health Stroke Scale(NIHSS),and levels of inflammatory factor,including high sensitivity C-reactive protein(hs CRP),interleukin-6(IL-6)and interleukin-1β(IL-1β),were compared between the two groups before and after treatment.The clinical efficacy and incidence of adverse reactions of the two groups were observed.Result The total effective rate in the observation group was higher than that in the control group(95.24%vs.80.95%,P=0.043).After treatment,the MBFV,VABF,and BABF in the observation group were all higher than those in the control group(P<0.001),the NSE,Hcy,S100-βlevels and NIHSS scores were lower than those in the control group(P<0.001),and the hs-CRP,IL-6,and IL-1βlevels were lower than those in the control group(P<0.001).There was no statistically significant difference in the incidence of adverse reactions such as facial flushing,fatigue,palpitations,rash,and gastrointestinal discomfort between the two groups of patients within 2 weeks of treatment(P>0.05).Conclusion Ginkgo biloba diterpene lactone glucosamine combined with urinary kallidinogenase can improve hemodynamics and neural function,inhibiting inflammatory response.