丹红注射液联合依达拉奉注射液治疗急性期脑梗死的临床疗效研究

Clinical study of Danhong injection combined with edaravone injection in the treatment of acute cerebral infarction

目的分析丹红注射液联合依达拉奉注射液治疗急性期脑梗死的临床疗效。方法选取100例急性期脑梗死患者作为研究对象,按照治疗方法的不同分为对照组和观察组,每组50例。对照组患者给予丹红注射液治疗,观察组患者则给予依达拉奉注射液联合丹红注射液治疗。比较两组患者治疗前后神经功能缺损评分、日常生活能力评定量表(BI)评分、Fugl-Meyer运动功能评价量表(FMA)评分、认知功能评分,治疗后血液流变学指标水平,临床治疗效果。结果治疗前,两组患者的神经功能缺损评分、BI评分、上肢和下肢FMA评分、认知功能评分比较差异均无统计学意义(P>0.05);治疗后,两组患者的神经功能缺损评分、BI评分、上肢和下肢FMA评分、认知功能评分均较治疗前改善,且观察组患者的神经功能缺损评分(10.56±1.21)分低于对照组的(14.53±1.56)分,BI评分(92.56±3.21)分、上肢FMA评分(45.19±5.42)分、下肢FMA评分(30.56±1.21)分、认知功能评分(27.19±2.42)分均显著高于对照组的(84.52±3.13)、(36.14±5.67)、(24.53±1.56)、(26.19±2.01)分,差异具有统计学意义(P<0.05)。治疗后,观察组患者的红细胞压积、纤维蛋白原、全血粘度分别为(40.52±0.88)%、(3.65±0.31)g/L、(3.71±0.28)mPa·s,均显著低于对照组的(50.34±1.24)%、(4.82±0.41)g/L、(4.52±0.34)mPa·s,差异具有统计学意义(P<0.05)。观察组患者的临床治疗总有效率为94.00%,显著高于对照组的80.00%,差异具有统计学意义(P<0.05)。结论对急性期脑梗死患者施以依达拉奉注射液联合丹红注射液治疗疗效确切,值得肯定。

Objective To analyze the clinical efficacy of Danhong injection combined with edaravone injection in the treatment of acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction were divided into control group and observation group according to different treatment methods,with 50 cases in each group.The control group was treated with Danhong injection,and the observation group was treated with edaravone injection and Danhong injection.Both groups were compared in terms of neurological deficit score,Barthel index(BI)score,Fugl-Meyer assessment scale(FMA)score,cognitive function score,hemorheology index level after treatment,and clinical therapeutic effect.Results Before treatment,there were no statistically significant differences in neurological deficit score,BI score,FMA scores of upper limb and lower limb and cognitive function score between the two groups(P>0.05).After treatment,the neurological deficit score,BI score,FMA scores of upper limb and lower limb,cognitive function score in the two groups were improved compared with those before treatment in this group;the neurological deficit score of(10.56±1.21)points in the observation group was lower than that of(14.53±1.56)points in the control group;the observation group had BI score of(92.56±3.21)points,FMA score of upper limb of(45.19±5.42)points,FMA score of lower limb of(30.56±1.21)points and cognitive function score of(27.19±2.42)points,which were significantly higher than those of(84.52±3.13),(36.14±5.67),(24.53±1.56),and(26.19±2.01)points in the control group;the differences were statistically significant(P<0.05).After treatment,the hematocele,fibrinogen and whole blood viscosity in the observation group were(40.52±0.88)%,(3.65±0.31)g/L and(3.71±0.28)mPa·s,which were significantly lower than those of(50.34±1.24)%,(4.82±0.41)g/L and(4.52±0.34)mPa·s in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was 94.00%,which was significantly higher than that of 80.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Edaravone injection combined with Danhong injection is effective in the treatment of acute cerebral infarction,which is worth affirming.