康柏西普玻璃体内注射治疗白内障术后黄斑水肿的临床效果

Clinical effect of intravitreal injection of Conbercept in the treatment of macular edema after cataract surgery

目的分析康柏西普玻璃体内注射治疗白内障术后黄斑水肿的临床效果。方法90例白内障术后黄斑水肿患者,根据入院的先后顺序分为实验组和常规组,每组45例。常规组患者接受常规治疗,实验组患者接受玻璃体内注射康柏西普治疗。比较两组患者治疗前后最佳矫正视力(BCVA)、眼压、黄斑中心凹厚度(CMT)以及并发症发生情况。结果实验组治疗1周、1个月后的BCVA分别为(0.58±0.14)、(0.68±0.13),均高于常规组的(0.42±0.16)、(0.50±0.12),差异具有统计学意义(P<0.05)。实验组治疗1周、1个月后眼压分别为(18.38±1.45)、(15.49±1.24)mm Hg(1 mm Hg=0.133 kPa),均低于常规组的(22.96±1.62)、(19.73±1.31)mm Hg,差异具有统计学意义(P<0.05)。实验组治疗1周、1个月后CMT分别为(365.48±19.62)、(308.65±11.63)μm,均小于常规组的(401.19±27.33)、(374.25±17.53)μm,差异具有统计学意义(P<0.05)。实验组并发症发生率0低于常规组的15.56%,差异具有统计学意义(P<0.05)。结论玻璃体内注射康柏西普治疗白内障术后黄斑水肿的效果较为显著,能够有效改善患者的眼压以及CMT,对患者的视力恢复效果也较好,并发症发生率低,具有较高的安全性,可广泛应用于临床。

Objective To analyze the clinical effect of intravitreal injection of Conbercept in the treatment of macular edema after cataract surgery.Methods A total of 90 patients with macular edema after cataract surgery were divided into experimental group and conventional group according to the order of admission,with 45 cases in each group.The conventional group received the conventional treatment,and the experimental group received intravitreal injection of Conbercept.Both groups were compared in terms of best corrected visual acuity(BCVA),intraocular pressure,central macular thickness(CMT)before and after treatment,and the incidence of complications.Results BCVA of the experimental group were(0.58±0.14)and(0.68±0.13)after 1 week and 1 month of treatment,which were higher than those of(0.42±0.16)and(0.50±0.12)of the conventional group,and the differences were statistically significant(P<0.05).The intraocular pressure of the experimental group after 1 week and 1 month of treatment were(18.38±1.45)and(15.49±1.24)mm Hg(1 mm Hg=0.133 kPa),which were lower than those of(22.96±1.62)and(19.73±1.31)mm Hg of the conventional group,and the differences were statistically significant(P<0.05).After 1 week and 1 month of treatment,CMT of experimental group were(365.48±19.62)and(308.65±11.63)μm,which were less than those of(401.19±27.33)and(374.25±17.53)μm of the conventional group,and the differences were statistically significant(P<0.05).The complication rate of 0 in the experimental group was lower than that of 15.56%in the conventional group,and the difference was statistically significant(P<0.05).Conclusion The effect of intravitreal injection of Conbercept in the treatment of macular edema after cataract surgery is significant.It can effectively improve the intraocular pressure and CMT of patients,and has a good effect on visual recovery of patients,with a low complication rate and high safety,which can be widely used in clinical practice.