黄白健脾口服液对犊牛湿热泄泻的治疗效果分析

Effect evaluation of Huangbai Jianpi oral liquid on treating calves with dampness heat diarrhea

本试验旨在评价中兽药黄白健脾口服液对犊牛湿热泄泻的治疗效果。筛选符合犊牛湿热泄泻诊断标准的患病犊牛,并对其进行病原检测,给予黄白健脾口服液进行治疗。通过比较治疗前后犊牛的临床表现、血液生化指标变化及细胞因子水平变化,验证黄白健脾口服液对犊牛湿热泄泻的治疗效果。病原检测发现,在犊牛粪便中检测到冠状病毒、隐孢子虫、轮状病毒、大肠杆菌K99、贾第鞭毛虫等5种常见的可导致犊牛腹泻的病原,其中冠状病毒的感染率最高,为34.78%,混合感染比例为39.13%,另有32.61%的病例未检测到这5种常见病原。经黄白健脾口服液治疗,46头湿热泄泻犊牛中19头病牛完全康复,20头病牛明显好转,总有效率为84.78%。治疗前发病犊牛血清尿素氮水平显著高于对照组(P<0.05),尿酸、肌酐和IL-1β水平极显著高于对照组(P<0.01),总胆固醇、碱性磷酸酶、白蛋白及血磷、IL-10和TFF3水平极显著低于对照组(P<0.01)。经黄白健脾口服液治疗后,肌酐、尿素氮和IL-1β水平极显著低于治疗前(P<0.01),总胆固醇、碱性磷酸酶、白蛋白及血糖、IL-10和TFF3水平极显著高于治疗前(P<0.01)。综上,黄白健脾口服液对临床中犊牛湿热泄泻病例有较好的治疗效果,可作为治疗犊牛湿热泄泻潜在的补充或替代药物。

The purpose of this experiment was to study the treatment effect of Huangbai Jianpi oral liquid,a selfprescribed Chinese herbal compound,on calves with dampness heat diarrhea(DHD).According to the basic theory of Traditional Chinese Veterinary Medicine,the feasible syndrome differentiation standard of dampness heat diarrhea on calves was established.In accordance with the syndrome differentiation standard,46 calves conforming to the syndrome type were selected.Feces were collected for pathogen detection before treatment.The clinical manifestations and efficiency,serum biochemical index and cytokines were compared before and after treatment.The results showed that 5pathogens were detected from feces of DHD calves,among which the infection rate of coronavirus was the highest(34.78%),and the mixed infection rate was 39.13%,32.61% of the cases did not detect the five common pathogenic agents.After treatment with Huangbai Jianpi oral liquid,19 of 46 calves with damp-heat diarrhea recovered completely,and 20 of them improved obviously.The total effective rate was 84.78%.Before treatment,serum urea nitrogen was significantly higher than that of control group(P0.05),the levels of uric acid,creatinine and IL-1β were significantly higher than those of control group(P0.01),while the levels of total cholesterol,alkaline phosphatase,albumin,blood phosphorus,IL-10 and TFF3 were significantly lower than those of control group(P0.01).After treatment with Huangbai Jianpi oral liquid,the levels of creatinine,urea nitrogen and IL-1β were significantly lower than those before treatment(P0.01),while total cholesterol,alkaline phosphatase,albumin,blood glucose,IL-10 and TFF3 were significantly higher than those before treatment(P0.01).To sum up,Huangbai Jianpi oral liquid has a good therapeutic effect on the cases of calf damp-heat diarrhea in clinic,and can be used as a potential supplement and substitute medicine for calf damp-heat diarrhea.