循环亚油酸水平与动脉粥样硬化风险的因果关联:一项两样本孟德尔随机化研究

Causal Association between Circulating Linoleic Acid Levels and Risk of Atherosclerosis:A Two Sample Mendel Randomization Studys

目的:本文拟探讨遗传预测的循环亚油酸水平与不同部位动脉粥样硬化的因果关联。方法:采用两样本孟德尔随机化(Mendelian randomization,MR)研究方法,选择与亚油酸相关联的单核苷酸多态性位点(single nucleotide polymorphism,SNPs)作为工具变量(Instrument Variables,IVs),评估遗传预测的循环亚油酸水平与不同部位动脉粥样硬化的因果关联。结果:逆方差加权法(Inverse Variance Weighted,IVW)分析结果显示,遗传预测的循环亚油酸水平与冠状动脉粥样硬化风险存在显著正相关(OR=1.32,95%CI:1.09-1.61,P=0.005);循环亚油酸水平与脑动脉粥样硬化风险之间无因果关联(OR=1.18,95%CI:0.63-2.23,P=0.602)。循环亚油酸水平与外周动脉粥样硬化风险存在显著负相关(OR=0.55,95%CI:0.39-0.77,P=0.001)。循环亚油酸水平与其他动脉粥样硬化(不包括脑、冠状动脉和外周动脉)之间无显著的因果关联(OR=0.99,95%CI:0.81-1.21,P=0.916)。结论:遗传预测的循环亚油酸水平与冠状动脉粥样硬化及外周动脉硬化存在因果关联,亚油酸在动脉粥样硬化防治中的作用值得重视及进一步研究。

Objective:To explore the causal relationship between circulating linoleic acid levels predicted by genetics and atherosclerosis in different sites of the body.Methods:Two sample Mendelian randomization(MR)study was used to select single nucleotide polymorphisms(SNPs)associated with linoleic acid as instrument variables(IVs)to evaluate the causal relationship between circulating linoleic acid level predicted by inheritance and atherosclerosis in different sites.Results:The results of inverse variance weighted(IVW)analysis showed that circulating linoleic acid levels predicted by genetics was significantly positively correlated with the risk of coronary atherosclerosis(OR=1.32,95%CI:1.09-1.61,P-0.005).There was no causal relationship between circulating linoleic acid level and the risk of cerebral atherosclerosis(OR=1.18,95%CI:0.63-2.23,P=0.602).The level of circulating linoleic acid was negatively correlated with the risk of peripheral atherosclerosis(OR=0.55,95%CI:0.39-0.77,P-0.001).There was no significant causal relationship between circulating linoleic acid level and other atherosclerosis(excluding cerebral,coronary and peripheral arteries)(OR=0.99,95%CI:0.81-1.21,P-0.916).Conclusion:The circulating linoleic acid level predicted by genetics has a causal relationship with coronary atherosclerosis and peripheral atherosclerosis.The role of linoleic acid in the prevention and treatment of atherosclerosis deserves attention and further research.