嗅觉刺激对减轻新生儿操作性疼痛有效性的Meta分析

Effectivesness of Olfactory Stimulation in Alleviating Operant Pain in Neonates:a Metaanalysis

目的采用嗅觉刺激对减轻新生儿操作性疼痛的效果。方法计算机检索CNKI、WanFang Data、VIP、SinoMed、Pubmed、Web of Science、the Cochrane Library等数据库,搜集有关嗅觉刺激对缓解新生儿操作性疼痛效果的随机对照试验,检索时限为建库至2021年8月31日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Revman5.3进行Meta分析。结果共纳入15个RCT,包括1364位新生儿。Meta分析结果显示,嗅觉刺激对新生儿疼痛调节、操作过程中的心率、哭泣持续时间及血氧饱和度等改善效果均优于对照组。结论当前证据表明,嗅觉刺激在改善新生儿操作性疼痛及生理指标等方面效果优于常规护理。受纳入研究的数量及质量的限制,上述研究结论还待更多大样本、高质量的研究加以验证。

Objective To evaluate the effectiveness of olfactory stimulation in reducing procedural pain in newborns.Methods CNKI,WanFang Data,VIP,SinoMed,Pubmed,Web of Science,and the Cochrane Library were searched until August 31,2021 for randomized controlled trials on the effects of olfactory stimulation on procedural pain in newborns.Two reviewers independently screened literature,extracted data,and assessed the risk of bias of included studies.Meta-analysis was conducted using Revman 5.3.Results A total of 15RCTs including 1364 newborns were included in the meta-analysis.The results showed that olfactory stimulation had better effects than the control group in modulating newborn pain,heart rate during the procedure,duration of crying,and blood oxygen saturation.Conclusion Current evidence suggests that olfactory stimulation is more effective than routine care in improving procedural pain and physiological indicators in newborns.However,due to the limitations of the quantity and quality of included studies,the above conclusions still need to be validated by more large-sample and high-quality studies.