吉西他滨+顺铂时辰化疗诱导联合同步放化疗对局部晚期鼻咽癌的疗效

Efficacy of induction chronochemotherapy with gemcitabine and cisplatin regimen and concurrent radiochemotherapy in locally advanced nasopharyngeal carcinoma

目的观察吉西他滨+顺铂(GP)时辰化疗方案诱导联合同步放化疗对局部晚期鼻咽癌的疗效。方法84例局部晚期鼻咽癌患者随机采用常规GP(对照组)或时辰GP(观察组)方案诱导化疗联合同步放化疗,比较两组近期疗效、不良反应、细胞免疫功能和生活质量。结果观察组白细胞减少、中性粒细胞减少、血小板减少、呕吐、肾损伤和听力受损程度均轻于对照组(P<0.05),而CD3^(+)细胞、CD4^(+)细胞、CD4^(+)/CD8^(+)比值和Karnofsky功能状态评分均高于对照组(P<0.05)。结论GP时辰化疗可减少局部晚期鼻咽癌患者不良反应,提高细胞免疫功能和改善生活质量。

Objective To observe the efficacy of induction chronochemotherapy with gemcitabine and cisplatin(GP)regimen and concurrent radiochemotherapy in locally advanced nasopharyngeal carcinoma(LANPC).Methods Eighty-four LANPC patients were randomly treated by GP induction chemotherapy(control group)or chronochemotherapy with concurrent radiochemotherapy.Short-term efficacy,adverse reactions,cellular immune function and quality of life were compared between two groups.Results Compared with control group,leukopenia,neutropenia,thrombocytopenia,vomiting,renal injury and hearing impairment were lower,while CD3^(+)cells,CD4^(+)cells,CD4^(+)/CD8^(+)ratio,and KPS scores were higher(P<0.05)in observation group.Conclusion GP chronochemotherapy can reduce adverse reactions and improve cellular immune function and quality of life in LANPC patients.