中性粒细胞胞外陷阱在脓毒症发病机制中的作用

Role of neutrophil extracellular trap in the pathogenesis of sepsis

脓毒症的发病机制非常复杂,研究发现脓毒性休克患者血浆中的中性粒细胞胞外陷阱(NET)成分显著增加,与疾病严重程度和28 d死亡率呈正相关。NET被证实在推动脓毒症进展过程中发挥重要作用。该文对NET在脓毒症发病中的相关研究进行综述。

The pathogenesis of sepsis is very complicated.It has been found that the neutrophils extracellular trap(NET)components in the plasma have significantly increased in patients with septic shock,which was positively correlated with disease severity and 28-day mortality.NET has been proved to play an important role in promoting the progression of sepsis.This paper reviewed the relevant studies on NET in the pathogenesis of sepsis.