线粒体功能障碍引起的相关炎性疾病及靶向治疗

Related Inflammatory Diseases Caused by Mitochondrial Dysfunction and Targeted Therapy to Them

作为真核细胞中必不可少的细胞器,线粒体在能量代谢、维持氧化还原平衡和细胞凋亡调节中起着核心作用。线粒体功能障碍无论是由于线粒体自身受损、线粒体DNA基因突变或者是有缺陷的线粒体电子传递链、氧化应激,还是异常基因和炎性信号传导引起,都会对组织或器官造成一定的损伤或导致炎症的发生,如肾脏、肝脏、乳腺等器官或组织。本文总结了线粒体中重要组分包括线粒体DNA、细胞色素c和心磷脂的功能,及线粒体功能障碍引起的炎症疾病以及对线粒体功能障碍的治疗,以期为线粒体功能障碍与炎症疾病及靶向治疗提供更多技术支撑。

As an essential organelle in eukaryotic cells,mitochondria play a central role in energy metabolism,maintenance of redox balance and regulation of apoptosis.Mitochondrial dysfunction,whether caused by mitochondrial damage,mitochondrial DNA gene mutation or defective mitochondrial electron transport chain,oxidative stress,or abnormal genes and inflammatory signal transduction,will cause certain damages to tissues or organs or lead to inflammation,such as kidney,liver,breast and other organs or tissues.This paper summarized the functions of important components in mitochondria,including mitochondrial DNA,cytochrome c and cardiolipin,and the inflammatory diseases caused by mitochondrial dysfunction,as well as the treatment of mitochondrial dysfunction,aiming to provide more technical support for mitochondrial dysfunction,inflammatory diseases and targeted therapy.