中医疗法靶向干预SCF/c-kit信号通路治疗功能性消化不良机制研究进展

Research Progress in the Mechanism of Targeted Intervention of SCF/c-kit Signaling Pathway by TCM Therapy in Treating Functional Dyspepsia

功能性消化不良(FD)的病理机制尚未阐明,中医治疗FD优势明显,临床疗效确切,其中以中药复方、单味药及其成分和针灸等为代表的中医疗法在FD的临床治疗中具有重要地位。目前,针对FD的研究中干细胞因子(SCF)/c-kit信号转导的重要性日益凸显,并取得一定进展。中医疗法干预SCF/c-kit系统治疗FD的机制可能与其调节胃肠卡哈尔间质细胞、神经细胞和肥大细胞功能异常引起的胃肠动力障碍、十二指肠低度炎症和内脏敏感性增高有关。本文对中医疗法调控SCF/c-kit通路治疗FD进行综述,以期为临床治疗提供依据。

The pathological mechanism of functional dyspepsia(FD)has not been elucidated.TCM has obvious advantages in the treatment of FD and definite clinical efficacy.TCM therapy represented by TCM compounds,single TCM drugs and their components and acupuncture and moxibustion play an important role in the clinical treatment of FD.At present,the importance of stem cell factor(SCF)/c-kit signal transduction in FD research has become increasingly prominent and some progress has been made.The mechanism of TCM therapy intervention in the treatment of FD by SCF/c-kit system may be related to its regulation of gastrointestinal interstitial cells of Cajal,nerve cells and mast cells dysfunction,which is associated with gastrointestinal motility disorder,duodenal low-grade inflammation and increased visceral sensitivity.Based on this,this article reviewed the regulation of SCF/c-kit pathway in the treatment of FD through TCM therapy,in order to provide basis for clinical treatment.