短链脂肪酸在肿瘤免疫治疗中的作用及机制研究进展

Research progress on the role and mechanism of short-chain fatty acids in tumor immunotherapy

免疫治疗的临床应用显著提高了肿瘤患者的生存率,其机制除了其本身具有增强免疫细胞介导的抗肿瘤反应外,肠道微生物及其代谢产物的变化也发挥着重要作用。短链脂肪酸是结肠中细菌发酵未被小肠吸收的碳水化合物的主要产物,有研究表明短链脂肪酸具有免疫调节功能,可以影响肿瘤对免疫检查点抑制剂的应答。本文就近年来短链脂肪酸在肿瘤的免疫治疗过程中发挥作用的研究进展进行综述。

The clinical application of immunotherapy has significantly improved the survival rate of tumor patients,and its mechanism plays an important role in the change of gut microorganisms and their metabolites,in addition to its own anti-tumor response,which enhances immune cell mediation.Short-chain fatty acids are the main products of bacteria fermenting carbohydrates not absorbed by the small intestine in the colon,and studies have shown that short-chain fatty acids have immunomodulation function,which can affect the tumor's response to immuno-checkpoint inhibitors.This paper reviews the research progress of short-chain fatty acids in the immunotherapy process of tumors in recent years.