中药治疗糖尿病心肌病作用机制的研究进展

Research Progress on the Mechanism of Traditional Chinese Medicine in the Treatment of Diabetic Cardiomyopathy

糖尿病能够导致心脏结构和功能损伤,进而导致左心室肥厚、心肌纤维化,并最终诱发心力衰竭。糖尿病心肌病(DCM)是糖尿病患者死亡的原因之一,也是威胁人类生命健康和降低生活质量的慢性病之一。近年来随着传统医学的不断发展,关于中药治疗DCM的研究越来越多,但未见研究对其机制进行系统总结。本文主要从抗氧化应激、抗炎、抗细胞凋亡、抗心肌纤维化及其他作用几个方面综述了中药对DCM的作用机制,指出中药有效成分复杂多样,中药治疗DCM具有多靶点、多机制的特点,这对于临床筛选有效治疗靶点提供了更多选择。

Diabetic can cause damage to cardiac structure and function,cause left ventricular hypertrophy,myocardial fibrosis,and eventually cause heart failure.Diabetic cardiomyopathy(DCM)is one of the causes of death in diabetes patients,and also one of the chronic diseases that threaten human life and health and reduce the quality of life.With the continuous development of traditional medicine in recent years,there are more and more studies on the treatment of DCM with traditional Chinese medicine,but there is no systematic summary of its mechanism.This article mainly reviews the mechanism of action of traditional Chinese medicine on DCM from the perspectives of antioxidant stress,anti-inflammatory effects,anti apoptosis,anti myocardial fibrosis,and other aspects,and points out that the active ingredient of traditional Chinese medicine are complex and diverse,and the treatment of DCM with traditional Chinese medicine is characterized by multiple targets and mechanisms,which provides more options for clinical screening of effective therapeutic targets.