基于肠道菌群治疗糖尿病神经痛的研究进展

Research progress in the treatment of diabetic neuropathic pain based on intestinal flora

糖尿病神经痛(diabetic neuropathic pain, DNP)是糖尿病最常见、最复杂的并发症之一,近年来研究表明,肠道菌群可通过调节脂多糖、短链脂肪酸、胆汁酸以及支链氨基酸等相关因子,进而调控炎症反应、肠道通透性、葡萄糖代谢以及调节脂肪酸氧化、合成和能量消耗,达到治疗DNP的目的。该文就肠道菌群治疗DNP的相关机制进行总结,并对相关中西医干预措施进行整理,以期为临床治疗DNP提供新思路。

Diabetic neuropathic pain(DNP)is one of the most common and complex complications of diabetes.In recent years,studies have shown that gut microbiota can regulate inflammatory response,intestinal permeability,glucose metabolism,and fatty acid oxidation,synthesis,and energy consumption by regulating factors such as lipopolysaccharides,short chain fatty acids,bile acids,and branched chain amino acids,achieving the goal of treating DNP.This paper summarizes the relevant mechanisms of gut microbiota in the treatment of DNP,the relevant intervention measures of traditional Chinese and western medicine,in order to provide new ideas for clinical treatment of DNP.