基于队列研究饮茶对人群预防Ⅱ型糖尿病效果的meta分析

Meta analysis on effect of tea drinking on typeⅡdiabetes prevention in population based cohort study

目的 系统评价饮茶对人群预防Ⅱ型糖尿病的效果,为开展人群Ⅱ型糖尿病预防工作提供参考。方法 对中国知网(China national knowledge infrastructure,CNKI)、万方数据库、维普网、PubMed、Cochrane Library数据库有关饮茶对人群预防Ⅱ型糖尿病效果的队列研究进行全面检索,检索时间为2000年1月—2023年3月10日。主要暴露指标为饮茶,主要结局指标为患Ⅱ型糖尿病。采用Review Manager 5.3软件对研究结果进行meta分析。结果 本研究确定了13项队列研究,包括1097 442名参与者和53 566例Ⅱ型糖尿病病例,随访时间为5~24年。汇总调整后,与不饮茶人群相比,饮茶人群患Ⅱ型糖尿病的风险降低12%(HR=0.88,95%CI=0.78~0.99),其中饮用绿茶可以将人群患糖尿病的风险降低9%(HR=0.91,95%CI=0.84~0.99),饮茶≥4杯/天的人群综合发病风险比不饮茶人群的风险下降17%(HR=0.83,95%CI=0.71~0.98)。结论 饮茶有益于降低人群患Ⅱ型糖尿病的风险,建议居民在健康饮食的基础上,每天饮用至少4杯绿茶,以到达最好的预防效果。

Objective To systematically evaluate the effect of tea drinking on typeⅡdiabetes prevention inthe population,provide a reference for developing typeⅡdiabetes prevention inthe population.Methods A comprehensive search was performed for cohort studies about the effect of teadrinking on typeⅡdiabetes prevention inthe population from the databases of Chinese National Knowledge Infrastructure(CNKI),Wanfang database,VIP,PubMed,and Cochrane Library,and the retrieval time was from January 2000 to March 10,2023.The primary exposure index was teadrinking and the primary outcome index was typeⅡdiabetes.Review Manager 5.3 software was used to conduct the meta-analysis of the study results.Results Totally 13 cohort studies were identified,comprising 1097442 participants and 53566 typeⅡdiabetescases,with follow-up duration of 5-24 years.After pooled adjustment,compared with people who do not drink tea,those who drink tea had a 12%lower risk of typeⅡdiabetes(HR=0.88,95%CI=0.78-0.99),of which drinking green tea reduced the risk of diabetes by 9%(HR=0.91,95%CI=0.84-0.99),and those who drink tea≥4 cups/day had a 17%lower overall risk of the disease compared to those who do not drink tea(HR=0.83,95%CI=0.71-0.98).Conclusion The teadrinkingis beneficial for reducing the risk of typeⅡdiabetes in the population,and it is recommended that residentsconsume at least four cups of green tea per day on the basis of a healthy diet to achieve the best preventive effect.