非酒精性脂肪性肝病与结直肠腺瘤发病相关性的Meta分析

Correlation between non-alcoholic fatty liver disease and colorectal adenoma:A Meta-analysis

[目的]系统评价非酒精性脂肪性肝病(NAFLD)与结直肠腺瘤之间的关系。[方法]计算机检索中国知网、万方数据库、中国生物医学文献数据库、中国维普数据库、PubMed、Web of science、Embase、Cochrane图书馆等数据库,纳入涉及NAFLD与结直肠腺瘤关系的研究。根据文献纳入及排除标准筛选文献并评价质量,采用RevMan5.3对纳入文献进行Meta分析,stata15.0对文献进行发表偏移检验。[结果]最终纳入15篇研究,包括6401例结直肠腺瘤患者。Meta分析结果显示:NAFLD与结直肠腺瘤的关系密切(OR=1.58,95%CI:1.37~1.82,P<0.00001)。各研究组分析显示:在国内组与国外组、超声检查组与CT检查组以及病例对照研究组、队列研究组与横断面研究组中病例者与对照者相比均差异有统计学意义(P<0.05)。[结论]NAFLD与结直肠腺瘤发病具有一定相关性。

[Objective]To systematically evaluate the relationship between non-alcoholic fatty liver disease(NAFLD)and colorectal adenoma.[Methods]Research on the relationship between NAFLD and colorectal adenoma was retrieved from CNKI,Wanfang Database,CBM,China VIP Database,PubMed,Web of Science,Embase,Cochrane Library.According to the literature inclusion and exclusion criteria,the literature was screened and the quality was evaluated.Meta-analysis was conducted by RevMan 5.3software,and the publication bias test was conducted by stata 15.0.[Results]A total of 15studies involving 6401patients with colorectal adenoma were included.Meta-analysis results showed that NAFLD is closely related to colorectal adenoma(OR=1.58,95%CI:1.37-1.82,P<0.00001).Subgroup analysis showed that in the domestic subgroup and the foreign subgroup,the ultrasound examination subgroup and the CT examination subgroup,the case-control study subgroup,the cohort study subgroup and the cross-sectional study subgroup,there were differences between the case group and the control group(P<0.05).[Conclusion]NAFLD has a certain correlation with the incidence of colorectal adenoma.