血清IGF-1、HO-1水平与胃癌患者临床病理特征的相关性

Correlation between serum IGF-1,HO-1levels and clinicopathological features in patients with gastric cancer

[目的]分析血清胰岛素样生长因子-1(IGF-1)和血红素加氧酶-1(HO-1)水平与胃癌患者临床病理特征的相关性。[方法]前瞻纳入符合条件的160例胃癌患者,均于入院时检测血清IGF-1、HO-1水平,记录患者临床病理特征,分析血清IGF-1、HO-1水平与胃癌患者临床病理特征的关系。[结果]Ⅲ~Ⅳ期、合并淋巴结转移的胃癌患者血清IGF-1、HO-1水平分别高于Ⅰ~Ⅱ期及未合并淋巴结转移的患者,差异有统计学意义(P<0.05);不同发病部位、肿瘤直径、肿瘤分化程度、组织类型、病灶侵袭深度的胃癌患者血清IGF-1及HO-1水平比较,差异无统计学意义(P>0.05);绘制受试者工作曲线(ROC)发现,胃癌患者入院时血清IGF-1、HO-1水平单项评估及联合评估TNM病理分期、淋巴结转移的曲线下面积(AUC)均>0.80,均有一定评估预测价值。[结论]胃癌患者血清IGF-1、HO-1水平与患者临床病理特征中TNM病理分期、淋巴结转移有密切关系,并可用作评估和预测指标。

[Objective]To investigate the correlation between serum insulin-like growth factor-1(IGF-1),heme oxygenase-1(HO-1)levels and clinicopathological features in patients with gastric cancer.[Methods]The totals of 160eligible patients with gastric cancer treated in our hospital from January 2018to January 2020were prospectively enrolled,their serum IGF-1and HO-1levels were detected during admission,the clinicopathological features of the patients were recorded,the relationship between serum IGF-1,HO-1 levels and clinicopathological features of patients with gastric cancer was analyzed.[Results]The levels of IGF-1and HO-1in patients at stageⅢ-Ⅳand with lymph node metastasis were higher than those in patients at stageⅠ-Ⅱand without lymph node metastasis,with a statistical significant difference(P<0.05).Compared serum IGF-1and HO-1levels in gastric cancer patients with different lesion sites,tumor diameter,tumor differentiation degree,tissue type and lesion invasion depth,there was no statistical significant difference(P>0.05).The receiver operating curve(ROC)showed that the area under the curve(AUC)of serum IGF-1and HO-1levels in patients with gastric cancer alone and in combination evaluated the pathological stage and lymph node metastasis at admission were higher than 0.80,which had certain evaluation and prediction value.[Conclusion]Serum IGF-1and HO-1levels in patients with gastric cancer are closely related to TNM pathological stage and lymph node metastasis of patients in clinicopathological features,levels of serum IGF-1and HO-1of patients can be detected clinically,which can be used as the evaluation and prediction indexes.