羚羊角颗粒联合丙戊酸钠治疗小儿癫痫的临床效果

Clinical effect of Lingyangjiao Granules combined with Sodium Valproate in the treatment of epilepsy in children

目的探讨羚羊角颗粒联合丙戊酸钠治疗小儿癫痫的临床效果。方法选取2020年7月至2022年7月滕州市妇幼保健院收治的87例癫痫患儿作为研究对象,按照随机数字表法分为对照组(43例)和研究组(44例)。对照组采用丙戊酸钠治疗,研究组在对照组基础上加用羚羊角颗粒治疗。比较两组临床疗效、癫痫发作频率、持续时间、认知功能、血清S100β、神经元特异性烯醇化酶(NSE)及不良反应发生情况。结果研究组总有效率高于对照组(P<0.05)。治疗后,两组癫痫发作频率及持续时间均优于治疗前,且研究组优于对照组(P<0.05)。治疗后,两组中国修订韦氏儿童智力量表(WISC-CR)评分均高于治疗前(P<0.05);治疗后,两组WISC-CR评分比较,差异无统计学意义(P>0.05)。治疗后,两组血清S100β及NSE均低于治疗前,且研究组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论采用羚羊角颗粒联合丙戊酸钠治疗小儿癫痫,可有效提高临床疗效,改善患儿症状、认知功能及神经损伤,且不会增加不良反应发生风险。

Objective To investigate the clinical effect of Lingyangjiao Granules combined with Sodium Valproate in the treatment of epilepsy in children.Methods A total of 87 children with epilepsy admitted to Tengzhou Maternal and Child Health Hospital from July 2020 to July 2022 were selected as the research objects.According to the random number table method,they were divided into the control group(43 cases)and the study group(44 cases).The control group was treated with Sodium Valproate,and the study group was treated with Lingyangjiao Granules on the basis of the control group.The clinical efficacy,seizure frequency,duration,cognitive function,serum S100β,neuron specific enolase(NSE)and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the frequency and duration of seizures in both groups were better than those before treatment,and those in the study group were better than those in the control group(P<0.05).After treatment,Wechsler intelligence scale for children-Chinese revision(WISC-CR)scores in both groups were higher than those before treatment(P<0.05).After treatment,there were no significant differences in WISC-CR scores between the two groups(P>0.05).After treatment,serum S100βand NSE in both groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Lingyangjiao Granules combined with Sodium Valproate in the treatment of children with epilepsy can effectively improve clinical efficacy,symptoms,cognitive function and nerve damage,and will not increase the risk of adverse reactions.