甘油三酯葡萄糖乘积指数与脑卒中风险关联的病例对照研究

Association between triglyceride-glucose index and risk of stroke:case-control study

[目的]探讨胰岛素抵抗的替代标志物甘油三酯葡萄糖乘积(TyG)指数与脑卒中患病风险的关联。[方法]数据来源于2017—2018年“京津冀地区生活社区自然人群慢性病队列研究”天津现场基线调查。通过问卷调查、体格检查与实验室检查的方式收集数据,病例组与对照组根据性别相同、年龄±2岁进行1∶1匹配。采用条件Logistic回归模型分析TyG指数与脑卒中患病风险的关联。[结果]共536例研究对象纳入分析,病例组TyG指数比对照组升高(P<0.0001)。多因素条件Logistic回归模型分析结果显示,与TyG指数<8.38相比,8.38≤TyG指数<8.67、8.67≤TyG指数<9.10和TyG指数≥9.10时,脑卒中的风险[OR(95%CI)]分别为1.13(0.61,2.10)、1.47(0.78,2.74)和2.24(1.06,4.72)。[结论]TyG指数是脑卒中患病的独立危险因素,随着TyG指数水平的升高,脑卒中患病风险逐渐增加。

Aim To investigate the association between triglyceride-glucose(TyG)index,a substitute marker of insulin resistance,and the risk of stroke.Methods The data were obtained from the baseline survey of Tianjin region in the Cohort Study on Chronic Disease of Communities Natural Population in Beijing,Tianjin and Hebei in 2017—2018.Data were collected by questionnaire,physical examination and laboratory examination.The case group and control group were matched 1∶1 according to the same gender and age±2 years.Conditional Logistic regression model was used to analyze the association between TyG index and risk of stroke.Results A total of 536 patients were included in the analysis.The TyG index in the case group was higher than that in the control group(P<0.0001).Multivariate conditional Logistic regression analysis showed that compared with individuals with TyG index<8.38,the OR(95%CI)for stroke in the 8.38≤TyG index<8.67,8.67≤TyG index<9.10,TyG index≥9.10 were 1.13(0.61,2.10),1.47(0.78,2.74),2.24(1.06,4.72).Conclusion TyG index was an independent risk factor for stroke.With the increase of TyG index,the risk of stroke increased gradually.