血清HB-EGF和SAA水平对高血压患者颈动脉粥样硬化的诊断价值

Diagnostic value of serum HB-EGF and SAA levels in hypertensive patients with carotid atherosclerosis

[目的]研究血清肝素结合性表皮生长因子(HB-EGF)、血清淀粉样蛋白A(SAA)对高血压患者颈动脉粥样硬化(CAS)的诊断价值。[方法]选取高血压患者100例,根据颈动脉内膜中膜厚度(CIMT)诊断结果将其分为高血压组(n=42)、高血压CAS组(n=58);另选取同期体检的健康受试者50例,设为健康对照组。比较健康对照组、高血压组和高血压CAS组血清HB-EGF、SAA水平及CIMT;采用Pearson相关分析法分析100例高血压患者血清HB-EGF、SAA水平与CIMT的相关性;采用Logistic回归分析法分析CAS的危险因素;采用ROC曲线分析血清HB-EGF、SAA水平对高血压患者CAS的诊断价值。[结果]与健康对照组比较,高血压组和高血压CAS组血清HB-EGF、SAA水平显著升高(P<0.05),CIMT显著增加(P<0.05)。与高血压组比较,高血压CAS组血清HB-EGF、SAA水平显著升高(P<0.05),CIMT显著增加(P<0.05)。Pearson相关分析显示,血清HB-EGF、SAA水平与CIMT均表现为正相关(r=0.807,95%CI:0.7257~0.8662,P<0.001;r=0.765,95%CI:0.6688~0.8357,P<0.001)。Logistic回归分析显示,高HB-EGF、高SAA均是高血压患者发生CAS的危险因素(P<0.05)。ROC曲线分析显示,血清HB-EGF、SAA水平诊断CAS的最佳截断点分别为19.84μg/L、8.97 mg/L,两者单独及联合诊断CAS的AUC分别为0.811、0.810、0.875,两者联合诊断的价值高于单独诊断。[结论]血清HB-EGF、SAA水平在高血压CAS患者中显著升高,两者与CIMT均为正相关,且对高血压CAS具有较高的诊断效能。

Aim To study the diagnostic value of serum heparin-binding epidermal growth factor(HB-EGF)and serum amyloid A(SAA)in hypertensive patients with carotid atherosclerosis(CAS).Methods A total of 100 hypertensive patients were selected and divided into hypertension group(n=42)and hypertension CAS group(n=58);another 50 healthy subjects who underwent physical examination during the same period were selected as the healthy control group.The serum HB-EGF,SAA levels and CIMT in healthy control group,hypertension group and hypertension CAS group were compared.Pearson correlation analysis was used to test the correlation between serum HB-EGF,SAA levels and CIMT.Logistic regression analysis was used to analyze the risk factors of CAS.ROC curve was used to analyze the diagnostic value of serum HB-EGF and SAA levels for CAS in hypertensive patients.Results Compared with the healthy control group,the serum levels of HB-EGF and SAA in the hypertension group and the hypertension CAS group were significantly increased(P<0.05),and the CIMT was significantly increased(P<0.05).Compared with the hypertension group,the serum HB-EGF and SAA levels in the hypertension CAS group were significantly increased(P<0.05),and the CIMT was significantly increased(P<0.05).Pearson correlation analysis showed that serum HB-EGF and SAA levels were positively correlated with CIMT(r=0.807,95%CI:0.7257~0.8662,P<0.001;r=0.765,95%CI:0.6688~0.8357,P<0.001).Logistic regression analysis showed that high HB-EGF and high SAA were both risk factors for CAS in hypertensive patients(P<0.05).The ROC curve showed that the optimal cut-off points of serum HB-EGF and SAA levels for diagnosing CAS were 19.84μg/L and 8.97 mg/L,respectively.The AUC for diagnosing CAS alone and in combination were 0.811,0.810 and 0.875,respectively,the value of combined diagnosis of the two was higher than that of single diagnosis.Conclusion Serum HB-EGF and SAA levels were significantly increased in hypertensive CAS patients,and both were positively correlated with CIMT,which has high diagnostic efficacy for hypertensive CAS.