摘要
细胞外囊泡(EV)是由各种活细胞分泌的纳米级大小的双层脂质囊状物。细胞外囊泡可以在细胞之间转运DNA、RNA和蛋白,是细胞间信息传递的重要部分。microRNA是一类小的非编码RNA,其通过与靶向mRNA 3′UTR区域结合,促进mRNA的降解或抑制蛋白的合成。文章着重讨论了microRNA产生的过程、细胞外囊泡作为microRNA的载体在细胞之间传递信息,以及EV-miRNA在心血管相关疾病中的重要作用。
Extracellular vesicles(EV)are nano-sized lipid bilayer vesicles,which were released by every cell type.EV can transfer DNA,RNA and protein among cells,which is a key part of signaling transduction among cells.microRNA is a small non-coding RNA molecular,which can bind to 3′UTR sequence of targeted mRNA,and facilitate mRNA degradation or block protein generation.This study focuses on the generation of microRNA and how EV transfer microRNA a mong cells,as well as the function of EV-miRNA in cardiovascular diseases.
作者
杨盛兰
丁楠
殷中伟
陈琛
YANG Shenglan;DING Nan;YIN Zhongwei;CHEN Chen(Department of Cardiology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Division of Cardiology and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)
出处
《中国动脉硬化杂志》
CAS
2023年第7期617-624,共8页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目资助(82100375)。
